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Table 1 Characteristics of the 22 cDNAs found to be overexpressed in the antropyloric tumors of 8-week-old TFF1 null mice

From: TreFoil Factor 1 (TFF1/pS2) Deficiency Activates the Unfolded Protein Response

Panel Functional Groupa Gene/Protein Name Accession Numbers Total Probesb Enriched Probesc Coordinatesd Nbe
A Oncogenes Tumor suppressors Cell cycle regulators Cyclin D1 S78355 + + A6f 1
B Stress response 78-kDa glucose regulated protein (GRP78) D78645 + + B1m 2
Ion channels & transport ERp72 endoplasmic reticulum stress protein J05186 + + B1k 3
Modulators, uPAR1; Urokinase plasminogen activator surface receptor X62700 + + B3i 4
effectors & intracellular transducers 58-kDa inhibitor of RNA-activated protein kinase U28423 + + B5i 5
C Apoptosis DNA synthesis, repair & recombination BAD protein L37296 ND + C1d 8
Blk (B lymphocyte kinase) M30903 ND + C2j 9
Chop 10 X67083 ND + C3a 10
Clusterin L08235 ND + C3b 11
Defender against cell death (DAD1) U83628 ND + C3d 12
HR21spA D49429 ND + C6h 13
D Transcription factors Ets-related protein PEA 3 X63190 + + D3a 6
DNA-binding proteins Nucleobindin M96823 ND + D5j 14
E Receptors CD44 antigen M27129 + + E6e 7
Cell surface antigen & cell adhesion CD14 monocyte differentiation antigen precursor M34510 ND + E6h 15
F Cell-cell communication Endothelial ligand for L-selectin (GLYCAM 1) M93428 ND + F1i 16
Cytoskeleton & motility Myosin light subunit 1 atrial/fetal isoform (MLC1A;MLCEMB) M19436 ND + F5l 17
Protein turnover Gelatinase B membrane-type matrix X72795 ND + F6n 18
metalloproteinase X83536 ND + F7c 19
Protease nexin 1 (PN-1) X70296 ND + F7d 20
Serine protease inhibitor 2-2 M64086 ND + F7j 21
Serine protease inhibitor 2.4 X69832 ND + F7k 22
  1. a The 588 mouse cDNAs immobilized in dots on nylon membrane are arranged by the manufacturer in 6 panels (A to F) in which several functional groups are represented
  2. b +, up-regulated genes; ND, no difference
  3. c +, up regulated genes
  4. d Coordinates from the Atlas™ Mouse cDNA Expression Array (Clontech, Palo Alto, CA)
  5. e Identification numbers corresponding to Figure 2