Table 1 Characteristics of the 22 cDNAs found to be overexpressed in the antropyloric tumors of 8-week-old TFF1 null mice
From: TreFoil Factor 1 (TFF1/pS2) Deficiency Activates the Unfolded Protein Response
Panel | Functional Groupa | Gene/Protein Name | Accession Numbers | Total Probesb | Enriched Probesc | Coordinatesd | Nbe |
|---|---|---|---|---|---|---|---|
A | Oncogenes Tumor suppressors Cell cycle regulators | Cyclin D1 | S78355 | + | + | A6f | 1 |
B | Stress response | 78-kDa glucose regulated protein (GRP78) | D78645 | + | + | B1m | 2 |
Ion channels & transport | ERp72 endoplasmic reticulum stress protein | J05186 | + | + | B1k | 3 | |
Modulators, | uPAR1; Urokinase plasminogen activator surface receptor | X62700 | + | + | B3i | 4 | |
effectors & intracellular transducers | 58-kDa inhibitor of RNA-activated protein kinase | U28423 | + | + | B5i | 5 | |
C | Apoptosis DNA synthesis, repair & recombination | BAD protein | L37296 | ND | + | C1d | 8 |
Blk (B lymphocyte kinase) | M30903 | ND | + | C2j | 9 | ||
Chop 10 | X67083 | ND | + | C3a | 10 | ||
Clusterin | L08235 | ND | + | C3b | 11 | ||
Defender against cell death (DAD1) | U83628 | ND | + | C3d | 12 | ||
HR21spA | D49429 | ND | + | C6h | 13 | ||
D | Transcription factors | Ets-related protein PEA 3 | X63190 | + | + | D3a | 6 |
DNA-binding proteins | Nucleobindin | M96823 | ND | + | D5j | 14 | |
E | Receptors | CD44 antigen | M27129 | + | + | E6e | 7 |
Cell surface antigen & cell adhesion | CD14 monocyte differentiation antigen precursor | M34510 | ND | + | E6h | 15 | |
F | Cell-cell communication | Endothelial ligand for L-selectin (GLYCAM 1) | M93428 | ND | + | F1i | 16 |
Cytoskeleton & motility | Myosin light subunit 1 atrial/fetal isoform (MLC1A;MLCEMB) | M19436 | ND | + | F5l | 17 | |
Protein turnover | Gelatinase B membrane-type matrix | X72795 | ND | + | F6n | 18 | |
metalloproteinase | X83536 | ND | + | F7c | 19 | ||
Protease nexin 1 (PN-1) | X70296 | ND | + | F7d | 20 | ||
Serine protease inhibitor 2-2 | M64086 | ND | + | F7j | 21 | ||
Serine protease inhibitor 2.4 | X69832 | ND | + | F7k | 22 |