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Fig. 1 | Molecular Medicine

Fig. 1

From: Poly(ADP-ribose) Polymerase is a Regulator of Chemokine Production: Relevance for the Pathogenesis of Shock and Inflammation

Fig. 1

Inhibition of LPS-induced chemokine production by PARP-1 deficiency of by inhibition of the catalytic activity of PARP by PJ-34. (A) PARP-1-deficient fibroblasts fail to produce MIP-1α and MIP-2 in response to 10 µg/ml LPS stimulation; n = 6 per group. (B) Dose-dependent suppression by PJ34 of MIP-1α and MIP-2 production in J774 macrophages stimulated with LPS (10 µg/ml), n = 6 per group.

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Molecular Medicine

ISSN: 1528-3658