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Fig. 1 | Molecular Medicine

Fig. 1

From: The 55-kD Tumor Necrosis Factor Receptor and CD95 Independently Signal Murine Hepatocyte Apoptosis and Subsequent Liver Failure

Fig. 1

Time course of DNA fragmentation and cell lysis in murine hepatocytes exposed to anti-CD95 or TNF in the presence or absence of ActD

Hepatocytes from BALB/c mice were incubated in RPMI1640 without further additions, or with 333 nM ActD, 100 ng/ml TNF, 100 ng/ml anti-CD95, or combinations of ActD and TNF or anti-CD95. After the indicated time periods, LDH release (A) and DNA fragmentation (B) were determined. DNA fragmentation is given as the original absorbance minus the average absorbance of untreated control cells. Data are means of triplicate determinations ± SD.

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