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Fig. 1 | Molecular Medicine

Fig. 1

From: Retroviral Vector Design for Gene Therapy of Cancer: Specific Inhibition and Tagging of BCR-ABLp190 Cells

Fig. 1

CD5-recombinant retroviruses encoding BCR-ABL p190 antisense (MFGA190CD5) and sense transcripts (MFGS190CD5)

(A) Proviral structure of the vectors. The MFG retroviral vector (23) incorporates 61 nucleotides spanning the BCR-ABL fusion junction (A) and a 1218-bp sequence of the human CD5 cDNA encoding the complete extracytoplasmic region. The vector does not contain a selectable marker. (B) Nucleotide sequence of the BCR-ABL fusion junction carried by the retroviral vectors in either antisense or sense orientations. (C) Diagrammatic representation of the human CD5 protein. The portion included in the retroviral vectors is indicated (δhCD5). EX, extracytoplasmic domain; TM, transmembrane domain; CY, cytoplasmic domain.

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Molecular Medicine

ISSN: 1528-3658