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Table 2 Correlation of M ϕ sensitivity to LeTx with ability to mount an oxidative burst

From: Role of Macrophage Oxidative Burst in the Action of Anthrax Lethal Toxin

 

PMA-Induced O2− Productiona

LeTx-Cytotoxicityb

 

(nmol/107 cells/hr)

(Relative Activity)

(% of Maximal Release)

(Relative Activity)

A. Murine Lines

    

J774

21

100%

60

100%

J774.16

34

162

69

115

3C3

14

67

52

87

D-9

11

52

45

75

RAW264.7

75

357

79

134

IC -21

<1

<5

0

0

B. 1° Human Monocytes

    

LN (CGD Patient)

0

0

<1

<2

PH (Control)

23

109

44

73

  1. aSuperoxide anion production was determined by cytochrome c reduction assay after addition of 10 ng/ml PMA, as described in Fig. 1.
  2. bCytotoxicity was assayed by 51Cr-release, as described in Fig. 1. Relative activities are compared using values derived from J774 Mϕ line as the 100% standard (see text).
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Molecular Medicine

ISSN: 1528-3658