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Table 1 Incubation times to onset of disease and death

From: High Prion and PrPSc Levels but Delayed Onset of Disease in Scrapie-Inoculated Mice Heterozygous for a Disrupted PrP Gene

Genotype of Host   Prion Inoculum  
Mouse (RML)   Hamster (Sc237)
Prn-p +/+ a    
Disease 158 ± 11   ND (>600)
Death 171 ± 11   ---
Prn-p 0/+    
Disease 290 ± 33 (n = 19)   >600 (n = 9)
Death 415 ± 30 (n = 15)   ---
Prn-p0/+/SHaPrP0/+    
Disease 260 ± 22 (n = 15)b   67 ± 4 (n = 9)
Death 280 ± 23 (n = 12)   72 ± 7 (n = 6)
Prn-p0/0/SHaPrP0/+    
Disease 323 ± 60 (n = 18)   58 ± 2 (n = 6)c
Death 341 ± 60 (n = 16)   60 ± 5 (n = 9)
Prn-p 0/0    
Disease >600 (n = 10)   >600 (n = 5)
Death ---   ---
  1. Two to four mice from each group were sacrificed after showing disease symptoms.
  2. aData from (28).
  3. bOne mouse died at 143 days and was not included in the average.
  4. cThree mice were found dead without having been diagnosed.