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Table 1 Lymphocyte and erythrocyte values of six patients

From: Clonal Hematopoiesis and Acquired Thalassemia in Common Variable Immunodeficiency

Patient and Relative Identification   Lymphocyte Values    Erythrocyte Values   
Patient Sex Relation Diagnosis % B Cells CD 4/8 Ratio Hb MCV HbA HbA2 HbF α/β Ratio
1 M Proband CVID 14% 5.0 7.8 67 97.6% 2.4% <1.0% 1.4a
  M Father 16.5 89 97.5% 2.5% <1.0% 0.97
  F Mother 11% 1.8 12.8 86 97.5% 2.5% <1.0% 0.90
2 F Proband CVID 7% 4.8 7.9 63 97.8% 2.2% <1.0% 0.76a
  F Mother 13.2 93 97.3% 1.7% <1.0% 0.96
3 M Proband CVID 3% 2.7 13.8 75 97.5% 2.9% <1.0% 1.15
  M Father 16.1 85
  F Mother 13.0 89
4 M Proband CVID 13% 0.8 11.9 79 98.1% 1.9% <1.0% 0.90
5 F Proband CVID 7% 1.5 12.3 81 97.8% 2.2% <1.0% 1.03
6 F Proband CVID 6% 0.5 14.4 92 97.7% 2.3% <1.0% 1.12
  1. M, male; F, female. B cells, CD19+ lymphocytes among peripheral blood lymphocytes (nl = 5.7–15.3%). CD4/8 ratio = ratio of CD4+ CD8+ lymphocytes (nl = 1.5–2.5). Hb = hemoglobin (nl = 12–16 gm/dl [female], 14–18 gm/dl [male]). MCV, mean corpuscular volume (nl = 83–99 mm3), α/β ratio, ratio of β to β globin synthesis in reticulocytes (nl = 0.90–1.10, established in our laboratory by study of reticulocyte enriched aliquots (7) of 30 nonanemic, nonmicrocytic subjects).
  2. aGlobin synthesis ratio confirmed by repeated measurements.