TY - JOUR AU - Michalek, S. M. AU - Moore, R. N. AU - McGhee, J. R. AU - Rosenstreich, D. L. AU - Mergenhagen, S. E. PY - 1980 DA - 1980// TI - The primary role of lymphoreticular cells in the mediation of host responses to bacterial endotoxin JO - J. Inf. Dis. VL - 141 UR - https://doi.org/10.1093/infdis/141.1.55 DO - 10.1093/infdis/141.1.55 ID - Michalek1980 ER - TY - JOUR AU - Galanos, C. AU - Freudenberg, M. A. PY - 1993 DA - 1993// TI - Mechanisms of endotoxin shock and endotoxin hypersensitivity JO - Immunobiology VL - 187 UR - https://doi.org/10.1016/S0171-2985(11)80349-9 DO - 10.1016/S0171-2985(11)80349-9 ID - Galanos1993 ER - TY - JOUR AU - Freudenberg, M. A. AU - Keppler, D. AU - Galanos, C. PY - 1986 DA - 1986// TI - Requirement for lipopolysaccharide-responsive macrophages in galactosamine-induced sensitization to endotoxin JO - Inf. Immun. VL - 51 ID - Freudenberg1986 ER - TY - JOUR AU - Beutler, B. AU - Mahoney, J. AU - Trang, N. AU - Pekala, P. AU - Cerami, A. PY - 1985 DA - 1985// TI - Purification of cachectin, a lipoprotein lipase-suppressing hormone secreted by endotoxin-induced RAW 264.7 cells JO - J. Exp. Med. VL - 161 UR - https://doi.org/10.1084/jem.161.5.984 DO - 10.1084/jem.161.5.984 ID - Beutler1985 ER - TY - JOUR AU - Beutler, B. AU - Greenwald, D. AU - Hulmes, J. D. PY - 1985 DA - 1985// TI - Identity of tumour necrosis factor and the macrophage-secreted factor cachectin JO - Nature VL - 316 UR - https://doi.org/10.1038/316552a0 DO - 10.1038/316552a0 ID - Beutler1985 ER - TY - JOUR AU - Beutler, B. AU - Milsark, I. W. AU - Cerami, A. PY - 1985 DA - 1985// TI - Passive immunization against cachectin/tumor necrosis factor (TNF) protects mice from the lethal effect of endotoxin JO - Science VL - 229 UR - https://doi.org/10.1126/science.3895437 DO - 10.1126/science.3895437 ID - Beutler1985 ER - TY - JOUR AU - Tracey, K. J. AU - Beutler, B. AU - Lowry, S. F. PY - 1986 DA - 1986// TI - Shock and tissue injury induced by recombinant human cachectin JO - Science VL - 234 UR - https://doi.org/10.1126/science.3764421 DO - 10.1126/science.3764421 ID - Tracey1986 ER - TY - JOUR AU - Beutler, B. AU - Krochin, N. AU - Milsark, I. W. AU - Luedke, C. AU - Cerami, A. PY - 1986 DA - 1986// TI - Control of cachectin (tumor necrosis factor) synthesis: mechanisms of endotoxin resistance JO - Science VL - 232 UR - https://doi.org/10.1126/science.3754653 DO - 10.1126/science.3754653 ID - Beutler1986 ER - TY - JOUR AU - Wright, S. D. AU - Ramos, R. A. AU - Tobias, P. S. AU - Ulevitch, R. J. AU - Mathison, J. C. PY - 1990 DA - 1990// TI - CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein JO - Science VL - 249 UR - https://doi.org/10.1126/science.1698311 DO - 10.1126/science.1698311 ID - Wright1990 ER - TY - JOUR AU - Hailman, E. AU - Lichenstein, H. S. AU - Wurfel, M. M. PY - 1994 DA - 1994// TI - Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD 14 JO - J. Exp. Med. VL - 179 UR - https://doi.org/10.1084/jem.179.1.269 DO - 10.1084/jem.179.1.269 ID - Hailman1994 ER - TY - JOUR AU - Watson, J. AU - Kelly, K. AU - Largen, M. AU - Taylor, B. A. PY - 1978 DA - 1978// TI - The genetic mapping of a defective LPS response gene in C3H/HeJ mice JO - J. Immunol. VL - 120 ID - Watson1978 ER - TY - JOUR AU - Watson, J. AU - Riblet, R. AU - Taylor, B. A. PY - 1977 DA - 1977// TI - The response of recombinant inbred strains of mice to bacterial lipopolysaccharides JO - J. Immunol. VL - 118 ID - Watson1977 ER - TY - CHAP AU - Vogel, S. N. ED - Beutler, B. PY - 1992 DA - 1992// TI - The Lps gene: Insights into the genetic and molecular basis of LPS responsiveness and macrophage differentiation BT - Tumor Necrosis Factors: The Molecules and Their Emerging Role in Medicine PB - Raven Press CY - New York ID - Vogel1992 ER - TY - JOUR AU - Shakhov, A. N. AU - Collart, M. A. AU - Vassalli, P. AU - Nedospasov, S. A. AU - Jongeneel, C. V. PY - 1990 DA - 1990// TI - κB-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor α gene in primary macrophages JO - J. Exp. Med. VL - 171 UR - https://doi.org/10.1084/jem.171.1.35 DO - 10.1084/jem.171.1.35 ID - Shakhov1990 ER - TY - JOUR AU - Han, J. AU - Brown, T. AU - Beutler, B. PY - 1990 DA - 1990// TI - Endotoxin-responsive sequences control cachectin/TNF biosynthesis at the translational level JO - J. Exp. Med. VL - 171 UR - https://doi.org/10.1084/jem.171.2.465 DO - 10.1084/jem.171.2.465 ID - Han1990 ER - TY - JOUR AU - Kruys, V. AU - Marinx, O. AU - Shaw, G. AU - Deschamps, J. AU - Huez, G. PY - 1989 DA - 1989// TI - Translational blockade imposed by cytokine-derived UA-rich sequences JO - Science VL - 245 UR - https://doi.org/10.1126/science.2672333 DO - 10.1126/science.2672333 ID - Kruys1989 ER - TY - JOUR AU - Han, J. AU - Thompson, P. AU - Beutler, B. PY - 1990 DA - 1990// TI - Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/TNF synthesis at separate points in the signalling pathway JO - J. Exp. Med. VL - 172 UR - https://doi.org/10.1084/jem.172.1.391 DO - 10.1084/jem.172.1.391 ID - Han1990 ER - TY - JOUR AU - Young, P. AU - McDonnell, P. AU - Dunnington, D. AU - Hand, A. AU - Laydon, J. AU - Lee, J. PY - 1993 DA - 1993// TI - Pyridinyl imidazoles inhibit IL-1 and TNF production at the protein level JO - Agents Actions VL - 39 UR - https://doi.org/10.1007/BF01972723 DO - 10.1007/BF01972723 ID - Young1993 ER - TY - JOUR AU - Kruys, V. AU - Thompson, P. AU - Beutler, B. PY - 1993 DA - 1993// TI - Extinction of the tumor necrosis factor locus, and of genes encoding the lipopolysaccharide signaling pathway JO - J. Exp. Med. VL - 177 UR - https://doi.org/10.1084/jem.177.5.1383 DO - 10.1084/jem.177.5.1383 ID - Kruys1993 ER - TY - JOUR AU - Geng, Y. AU - Zhang, B. AU - Lotz, M. PY - 1993 DA - 1993// TI - Protein tyrosine kinase activation is required for lipopolysaccharide induction of cytokines in human blood monocytes JO - J. Immunol. VL - 151 ID - Geng1993 ER - TY - JOUR AU - Weinstein, S. L. AU - Gold, M. R. AU - DeFranco, A. L. PY - 1991 DA - 1991// TI - Bacterial lipopolysaccharide stimulates protein tyrosine phosphorylation in macrophages JO - Proc. Natl. Acad. Sci. U.S.A. VL - 88 UR - https://doi.org/10.1073/pnas.88.10.4148 DO - 10.1073/pnas.88.10.4148 ID - Weinstein1991 ER - TY - JOUR AU - Novogrodsky, A. AU - Vanichkin, A. AU - Patya, M. AU - Gazit, A. AU - Osherov, N. AU - Levitzki, A. PY - 1994 DA - 1994// TI - Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors JO - Science VL - 264 UR - https://doi.org/10.1126/science.8191285 DO - 10.1126/science.8191285 ID - Novogrodsky1994 ER - TY - JOUR AU - Cobb, M. H. AU - Robbins, D. J. AU - Boulton, T. G. PY - 1991 DA - 1991// TI - ERKs, extracellular signal-regulated MAP2 kinases JO - Curr. Opin. Cell Biol. VL - 3 UR - https://doi.org/10.1016/0955-0674(91)90124-H DO - 10.1016/0955-0674(91)90124-H ID - Cobb1991 ER - TY - JOUR AU - Pazin, M. J. AU - Williams, L. T. PY - 1992 DA - 1992// TI - Triggering signaling cascades by receptor tyrosine kinases JO - Trends Biochem. Sci. VL - 17 UR - https://doi.org/10.1016/0968-0004(92)90003-R DO - 10.1016/0968-0004(92)90003-R ID - Pazin1992 ER - TY - JOUR AU - White, M. F. AU - Kahn, C. R. PY - 1994 DA - 1994// TI - The insulin signaling system JO - J. Biol. Chem. VL - 269 ID - White1994 ER - TY - JOUR AU - Warne, P. H. AU - Viciana, P. R. AU - Downward, J. PY - 1993 DA - 1993// TI - Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro JO - Nature VL - 364 UR - https://doi.org/10.1038/364352a0 DO - 10.1038/364352a0 ID - Warne1993 ER - TY - JOUR AU - Vojtek, A. B. AU - Hollenberg, S. M. AU - Cooper, J. A. PY - 1993 DA - 1993// TI - Mammalian Ras interacts directly with the serine/threonine kinase Raf JO - Cell VL - 74 UR - https://doi.org/10.1016/0092-8674(93)90307-C DO - 10.1016/0092-8674(93)90307-C ID - Vojtek1993 ER - TY - JOUR AU - Moodie, S. A. AU - Willumsen, B. M. AU - Weber, M. J. AU - Wolfman, A. PY - 1993 DA - 1993// TI - Complexes of Ras-GTP with Raf-1 and Mitogen-Activated Protein Kinase Kinase JO - Science VL - 260 UR - https://doi.org/10.1126/science.8503013 DO - 10.1126/science.8503013 ID - Moodie1993 ER - TY - JOUR AU - Kyriakis, J. M. AU - App, H. AU - Zhang, X. F. PY - 1992 DA - 1992// TI - Raf-1 activates MAP kinase-kinase JO - Nature VL - 358 UR - https://doi.org/10.1038/358417a0 DO - 10.1038/358417a0 ID - Kyriakis1992 ER - TY - JOUR AU - Robbins, D. J. AU - Zhen, E. AU - Owaki, H. PY - 1993 DA - 1993// TI - Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro JO - J. Biol. Chem. VL - 268 ID - Robbins1993 ER - TY - JOUR AU - Crews, C. M. AU - Alessandrini, A. AU - Erikson, R. L. PY - 1992 DA - 1992// TI - The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product JO - Science VL - 258 UR - https://doi.org/10.1126/science.1411546 DO - 10.1126/science.1411546 ID - Crews1992 ER - TY - JOUR AU - Seger, R. AU - Ahn, N. G. AU - Posada, J. PY - 1992 DA - 1992// TI - Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells JO - J. Biol. Chem. VL - 267 ID - Seger1992 ER - TY - JOUR AU - Boulton, T. G. AU - Cobb, M. H. PY - 1991 DA - 1991// TI - Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies JO - Cell Reg. VL - 2 UR - https://doi.org/10.1091/mbc.2.5.357 DO - 10.1091/mbc.2.5.357 ID - Boulton1991 ER - TY - JOUR AU - Boulton, T. G. AU - Yancopoulos, G. D. AU - Gregory, J. S. PY - 1990 DA - 1990// TI - An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control JO - Science VL - 249 UR - https://doi.org/10.1126/science.2164259 DO - 10.1126/science.2164259 ID - Boulton1990 ER - TY - JOUR AU - Boulton, T. G. AU - Nye, S. H. AU - Robbins, D. J. PY - 1991 DA - 1991// TI - ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF JO - Cell VL - 65 UR - https://doi.org/10.1016/0092-8674(91)90098-J DO - 10.1016/0092-8674(91)90098-J ID - Boulton1991 ER - TY - JOUR AU - Lee, H. AU - Ghose-Dastidar, J. AU - Winawer, S. AU - Friedman, E. PY - 1993 DA - 1993// TI - Signal transduction through extracellular signal-regulated kinase-like pp57 blocked in differentiated cells having low protein kinase Cbeta activity JO - J. Biol. Chem. VL - 268 ID - Lee1993 ER - TY - JOUR AU - Kyriakis, J. M. AU - Avruch, J. PY - 1990 DA - 1990// TI - pp54 Microtubule-associated protein 2 kinase. A novel serine/threonine protein kinase regulated by phosphorylation and stimulated by poly-L-lysine JO - J. Biol. Chem. VL - 265 ID - Kyriakis1990 ER - TY - JOUR AU - Cobb, M. H. AU - Helper, J. E. AU - Cheng, M. AU - Robbins, D. PY - 1994 DA - 1994// TI - The mitogen-activated protein kinases, ERK1 and ERK2 JO - Sem. Cancer Biol. VL - 5 ID - Cobb1994 ER - TY - JOUR AU - MacNicol, A. M. AU - Muslin, A. J. AU - Williams, L. T. PY - 1993 DA - 1993// TI - Raf-1 kinase is essential for early Xenopus development and mediates the induction of mesoderm by FGF JO - Cell VL - 73 UR - https://doi.org/10.1016/0092-8674(93)90143-E DO - 10.1016/0092-8674(93)90143-E ID - MacNicol1993 ER - TY - JOUR AU - Sontag, E. AU - Fedorov, S. AU - Kamibayashi, C. AU - Robbins, D. AU - Cobb, M. AU - Mumby, M. PY - 1993 DA - 1993// TI - The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the map kinase pathway and induces cell proliferation JO - Cell VL - 75 UR - https://doi.org/10.1016/0092-8674(93)90533-V DO - 10.1016/0092-8674(93)90533-V ID - Sontag1993 ER - TY - JOUR AU - Owaki, H. AU - Varma, R. AU - Gillis, B. PY - 1993 DA - 1993// TI - Raf-1 is required for T cell IL2 production JO - EMBO J. VL - 12 UR - https://doi.org/10.1002/j.1460-2075.1993.tb06121.x DO - 10.1002/j.1460-2075.1993.tb06121.x ID - Owaki1993 ER - TY - JOUR AU - Rayter, S. I. AU - Woodrow, M. AU - Lucas, S. C. AU - Cantrell, D. A. AU - Downward, J. PY - 1992 DA - 1992// TI - p21ras mediates control of IL-2 gene promoter function in T cell activation JO - EMBO J. VL - 11 UR - https://doi.org/10.1002/j.1460-2075.1992.tb05556.x DO - 10.1002/j.1460-2075.1992.tb05556.x ID - Rayter1992 ER - TY - JOUR AU - Han, J. AU - Lee, J. -. D. AU - Tobias, P. S. AU - Ulevitch, R. J. PY - 1993 DA - 1993// TI - Endotoxin induces rapid protein tyrosine phosphorylation in 70Z/3 cells expressing CD14 JO - J. Biol. Chem. VL - 268 ID - Han1993 ER - TY - JOUR AU - Dong, Z. AU - Qi, X. AU - Fidler, I. J. PY - 1993 DA - 1993// TI - Tyrosine phosphorylation of mitogen-activated protein kinases is necessary for activation of murine macrophages by natural and synthetic bacterial products JO - J. Exp. Med. VL - 177 UR - https://doi.org/10.1084/jem.177.4.1071 DO - 10.1084/jem.177.4.1071 ID - Dong1993 ER - TY - STD TI - Han J, Lee J-D, Bibbs L, Ulevitch RJ. (1994) A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science, in press. ID - ref45 ER - TY - JOUR AU - Bruder, J. T. AU - Heidecker, G. AU - Rapp, U. R. PY - 1992 DA - 1992// TI - Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase JO - Genes. Dev. VL - 6 UR - https://doi.org/10.1101/gad.6.4.545 DO - 10.1101/gad.6.4.545 ID - Bruder1992 ER - TY - JOUR AU - Heidecker, G. AU - Huleihel, M. AU - Cleveland, J. L. PY - 1990 DA - 1990// TI - Mutational activation of c-raf-1 and definition of the minimal transforming sequence JO - Mol. Cell. Biol. VL - 10 UR - https://doi.org/10.1128/MCB.10.6.2503 DO - 10.1128/MCB.10.6.2503 ID - Heidecker1990 ER - TY - JOUR AU - Feig, L. A. AU - Cooper, G. M. PY - 1988 DA - 1988// TI - Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP JO - Mol. Cell. Biol. VL - 8 UR - https://doi.org/10.1128/MCB.8.8.3235 DO - 10.1128/MCB.8.8.3235 ID - Feig1988 ER - TY - JOUR AU - Yamamoto, K. K. AU - Gonzalez, G. A. AU - Biggs, W. H. AU - Montminy, M. R. PY - 1988 DA - 1988// TI - Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB JO - Nature VL - 334 UR - https://doi.org/10.1038/334494a0 DO - 10.1038/334494a0 ID - Yamamoto1988 ER - TY - JOUR AU - Han, J. AU - Huez, G. AU - Beutler, B. PY - 1991 DA - 1991// TI - Interactive effects of the TNF promoter and 3′-untranslated regions JO - J. Immunol. VL - 146 ID - Han1991 ER - TY - JOUR AU - Boulton, T. G. AU - Cobb, M. H. PY - 1991 DA - 1991// TI - Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies JO - Cell Reg. VL - 2 UR - https://doi.org/10.1091/mbc.2.5.357 DO - 10.1091/mbc.2.5.357 ID - Boulton1991 ER - TY - JOUR AU - Chen, C. AU - Okayama, H. PY - 1987 DA - 1987// TI - High-efficiency transformation of mammalian cells by plasmid DNA JO - Mol. Cell. Biol. VL - 7 UR - https://doi.org/10.1128/MCB.7.8.2745 DO - 10.1128/MCB.7.8.2745 ID - Chen1987 ER - TY - JOUR AU - Gorman, C. M. AU - Moffat, L. F. AU - Howard, B. H. PY - 1982 DA - 1982// TI - Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells JO - Mol. Cell. Biol. VL - 2 UR - https://doi.org/10.1128/MCB.2.9.1044 DO - 10.1128/MCB.2.9.1044 ID - Gorman1982 ER - TY - JOUR AU - Beutler, B. AU - Brown, T. PY - 1991 DA - 1991// TI - A CAT reporter construct allows ultrasensitive estimation of TNF synthesis, and suggests that the TNF gene has been silenced in non-macrophage cell lines JO - J. Clin. Invest. VL - 87 UR - https://doi.org/10.1172/JCI115137 DO - 10.1172/JCI115137 ID - Beutler1991 ER - TY - JOUR AU - Manthey, C. L. AU - Brandes, M. E. AU - Perera, P. Y. AU - Vogel, S. N. PY - 1992 DA - 1992// TI - Taxol increases steady-state levels of lipopolysaccharide-inducible genes and protein-tyrosine phosphorylation in murine macrophages JO - J. Immunol. VL - 149 ID - Manthey1992 ER - TY - JOUR AU - Whitehurst, C. E. AU - Boulton, T. G. AU - Cobb, M. H. AU - Geppert, T. D. PY - 1992 DA - 1992// TI - Extracellular signal regulated kinases in T cells: Anti-CD3 and 4B-phorbol 12-myristate 13-acetate-induced phosphorylation and activation JO - J. Immunol. VL - 148 ID - Whitehurst1992 ER - TY - JOUR AU - Robbins, D. J. AU - Cobb, M. H. PY - 1992 DA - 1992// TI - ERK2 autophosphorylation on a subset of peptides phophorylated in intact cells by insulin and NGF: Analysis by peptide mapping JO - Mol. Biol. Cell VL - 3 UR - https://doi.org/10.1091/mbc.3.3.299 DO - 10.1091/mbc.3.3.299 ID - Robbins1992 ER - TY - JOUR AU - Karin, M. AU - Smeal, T. PY - 1992 DA - 1992// TI - Control of transcription factors by signal transduction pathways: the beginning of the end JO - Trends Biochem. Sci. VL - 17 UR - https://doi.org/10.1016/0968-0004(92)90012-X DO - 10.1016/0968-0004(92)90012-X ID - Karin1992 ER - TY - JOUR AU - D’rijard, B. AU - Hibi, M. AU - Wu, I. -. H. PY - 1994 DA - 1994// TI - JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain JO - Cell VL - 76 UR - https://doi.org/10.1016/0092-8674(94)90380-8 DO - 10.1016/0092-8674(94)90380-8 ID - D’rijard1994 ER - TY - JOUR AU - Hibi, M. AU - Lin, A. AU - Smeal, T. AU - Minden, A. AU - Karin, M. PY - 1993 DA - 1993// TI - Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain JO - Genes Dev. VL - 7 UR - https://doi.org/10.1101/gad.7.11.2135 DO - 10.1101/gad.7.11.2135 ID - Hibi1993 ER - TY - JOUR AU - Chou, S. Y. AU - Baichwal, V. AU - Ferrell, J. E. PY - 1992 DA - 1992// TI - Inhibition of c-jun DNA binding by mitogen activated protein kinase JO - Mol. Biol. Cell VL - 3 UR - https://doi.org/10.1091/mbc.3.10.1117 DO - 10.1091/mbc.3.10.1117 ID - Chou1992 ER - TY - JOUR AU - Alvarez, E. AU - Northwood, I. C. AU - Gonzalez, F. A. PY - 1991 DA - 1991// TI - Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase JO - J. Biol. Chem. VL - 266 ID - Alvarez1991 ER - TY - JOUR AU - Li, S. AU - Sedivy, J. M. PY - 1993 DA - 1993// TI - Raf-1 protein kinase activates the NF-κB transcription factor by dissociating the cytoplasmic NF-κB-IκB complex JO - Proc. Natl. Acad. Sci. U.S.A. VL - 90 UR - https://doi.org/10.1073/pnas.90.20.9247 DO - 10.1073/pnas.90.20.9247 ID - Li1993 ER -