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Table 2 GH mice treated with ACEi and AngII RA from age 6 to 12 weeks

From: The Molecular Basis of Increased Glomerulosclerosis after Blockade of the Renin Angiotensin System in Growth Hormone Transgenic Mice

Parameters (Units)

GH-Ctrl

GH-ACEi

GH-AngII RA

Body Weight (g)

47.6 ± 2.5

44.0 ± 1.7

45.1 ± 3.7

Body Weight Increase (%)

143 ± 11

144 ± 4

148 ± 17

Kidney Weight (mg)

467 ± 29

364 ± 26a

429 ± 39

Ratio KW/BW (×10−2)

98 ± 4

83 ± 5b

95 ± 7

Serum Creatinine (mg/dl)

0.60 ± 0.10

0.59 ± 0.07

0.37 ± 0.09

Urine Alb./Creat. (10−2 µg/mg)

4.12 ± 0.96

4.34 ± 0.85

4.43 ± 1.21

Glomerular Volume (105 µm3)

24.84 ± 0.85

24.02 ± 1.60

22.93 ± 1.63

Thymidine Labeling Index (%)

2.4 ± 0.3

3.5 ± 0.2c

3.3 ± 0.3d

  1. a p = 0.02, bp = 0.03, cp = 0.006, dp = 0.04, all comparisons versus GH-Ctrl.