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Table 2 GH mice treated with ACEi and AngII RA from age 6 to 12 weeks

From: The Molecular Basis of Increased Glomerulosclerosis after Blockade of the Renin Angiotensin System in Growth Hormone Transgenic Mice

Parameters (Units) GH-Ctrl GH-ACEi GH-AngII RA
Body Weight (g) 47.6 ± 2.5 44.0 ± 1.7 45.1 ± 3.7
Body Weight Increase (%) 143 ± 11 144 ± 4 148 ± 17
Kidney Weight (mg) 467 ± 29 364 ± 26a 429 ± 39
Ratio KW/BW (×10−2) 98 ± 4 83 ± 5b 95 ± 7
Serum Creatinine (mg/dl) 0.60 ± 0.10 0.59 ± 0.07 0.37 ± 0.09
Urine Alb./Creat. (10−2 µg/mg) 4.12 ± 0.96 4.34 ± 0.85 4.43 ± 1.21
Glomerular Volume (105 µm3) 24.84 ± 0.85 24.02 ± 1.60 22.93 ± 1.63
Thymidine Labeling Index (%) 2.4 ± 0.3 3.5 ± 0.2c 3.3 ± 0.3d
  1. a p = 0.02, bp = 0.03, cp = 0.006, dp = 0.04, all comparisons versus GH-Ctrl.