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Fig. 5 | Molecular Medicine

Fig. 5

From: IL-6 is associated to IGF-1Ec upregulation and Ec peptide secretion, from prostate tumors

Fig. 5

The effect of the IR on the expression of the IGF-1Ec isoform. GH binding to GHR leads to IGF-1Ea upregulation through JAK2/STA5 pathway. In a similar manner, IL-6 is initially produced by the cells of the immune system attacking prostate tumor.. Binding of IL-6 on IL-6R leads to the upregulation of the IGF-1Ec isoform and to the secretion of PEc as well as to IL-6 secretion from prostate cancer cells, by activating the JAK2/STAT3 pathway. PEc secretion leads to tumor progression and metastases acting in an autocrine and/or paracrine manner and it mobilizes MSC towards the tumor, prior to repair

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