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Fig. 2 | Molecular Medicine

Fig. 2

From: Uncoupling of glycolysis from glucose oxidation accompanies the development of heart failure with preserved ejection fraction

Fig. 2

Time dependent effects of a high salt diet (HSD) on palmitate oxidation, glucose oxidation, glycolysis, and lactate oxidation in Dahl salt-sensitive rat hearts. a Palmitate oxidation, (b) Glucose oxidation, (c) Lactate oxidation, (d) ATP production, (e) Glycolysis, and (f) Proton production were measured in hearts from Dahl salt-sensitive rats fed a low salt diet, 0.3% NaCl (Control) or a HSD, 8% NaCl, for 3, 6, or 9 weeks. Energy metabolic rates were assessed in isolated working hearts. Proton production was calculated based on glycolysis and glucose oxidation rates. Contribution to ATP production was calculated from the metabolic rates assessed using the isolated working heart perfusion in Dahl salt-sensitive rats. n = 3–5 * p < 0.05 compared to Control. Values shown as mean ± SEM

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Molecular Medicine

ISSN: 1528-3658