Uncoupling of glycolysis from glucose oxidation accompanies the development of heart failure with preserved ejection fraction

Table 1 Effect of a high salt diet (HSD) on in vivo cardiac function in Dahl salt-sensitive rats

	Control	3 weeks	6 weeks	9 weeks
EF (%)	83.79 ±1.44	82.21 ±2.50	84.91 ±1.14	76.21 ±2.19^T
FS (%)	54.60 ±1.69	53.12 ±2.57	54.45 ±2.39	47.64 ±2.34
LV Mass Corrected	962.88 ±43.45	1045.85 ±36.11	1167.85 ±38.96^*	1328.94 ±52.37^*#
IVSd (mm)	1.97 ±0.05	2.23 ±0.06^*	2.40 ±0.07^*	2.50 ±0.07^*#
LVIDd (mm)	7.91 ±0.12	7.32 ±0.14^*	7.45 ±0.09	7.52 ±0.20
LVPWd (mm)	1.98 ±0.03	2.23 ±0.06	2.49 ±0.10^*	2.50 ±0.08^*
IVSs (mm)	3.40 ±0.05	3.67 ±0.10	3.68 ±0.09	3.68 ±0.15
LVIDs (mm)	3.87 ±0.18	3.46 ±0.23	3.40 ±0.09	4.25 ±0.08
LVPWs (mm)	3.45 ±0.12	3.68 ±0.11	3.77 ±0.08	3.65 ±0.13
LV Vol;d	335.75 ±10.95	283.11 ±12.35^*	294.62 ±7.78	301.74 ±17.16
LV Vol;s	51.99 ±6.28	45.76 ±6.96	47.51 ±3.37	81.30 ±3.62^*#T
E/E’	19.04 ±2.18	20.49 ±1.95	18.82 ±1.22	18.29 ±1.51
E/A	1.60 ±0.11	1.64 ±0.07	1.33 ±0.15	1.40 ±0.20
E’/A’	0.98 ±0.04	0.85 ±0.03	0.81 ±0.02^*	0.76 ±0.07^*
Tei Index	0.65 ±0.03	0.72 ±0.04	0.78 ±0.05	0.76 ±0.05
E’	54.23 ±6.85	54.68 ±4.61	46.79 ±2.14	38.26 ±3.49
IVRT (ms)	24.32 ±0.60	22.68 ±0.68	27.97 ±1.76	28.13 ±1.63
IVCT (ms)	15.69 ±0.90	16.88 ±1.29	15.81 ±1.48	17.47 ±1.43
HR (bpm)	365.25 ±6.61	375.88 ±7.71	367.63 ±10.98	349.75 ±16.68
L Kidney/TL (g/cm)	0.31 ±0.01	0.34 ±0.01	0.34 ±0.01	0.38 ±0.03^*

In vivo cardiac function was measured via echocardiography in Dahl salt-sensitive rats fed a low salt diet, 0.3% NaCl (Control), or a high salt diet, 8% NaCl, for 3, 6, or 9 weeks. n = 5–8 * p < 0.05 compared to Control. * p < 0.05 compared to Control. ^# p < 0.05 compared to 3 weeks. ^T p < 0.05 compared to 6 weeks. n = 6–9 Values shown as mean ±SEM % Ejection fraction (%EF); % Fractional shortening (%FS); left ventricle (LV); Interventricular septum end diastole (IVSd); LV internal diameter end diastole (LVIDd); LV posterior wall thickness end diastole (LVPWd); Interventricular septum end systole (IVSs); LV internal diameter end systole (LVIDs); LV posterior wall thickness end systole (LVPWs); LV volume end diastole (LV Vol;d); LV volume end systole (LV Vol;s); Isovolumetic relaxation time (IVRT); Isovolumetic contraction time (IVCT); Tibia length (TL); Heart rate (HR)

ISSN: 1528-3658