Uncoupling of glycolysis from glucose oxidation accompanies the development of heart failure with preserved ejection fraction

Table 2 Effect of a high salt diet (HSD) on cardiac function ex vivo in Dahl salt-sensitive rats

	Control	3 weeks	6 weeks	9 weeks
Heart rate (beats●min^− 1)	277.9 ±7.3	290.8 ±8.6	278.7 ±6.1	266.9 ±22.9
Peak Systolic Pressure (mmHg)	109.9 ±1.0	107.8 ±2.6	110.8 ±1.7	107.5 ±6.7
Developed Pressure (mmHg)	41.9 ±2.8	38.5 ±3.8	42.6 ±2.2	43.1 ±7.0
Cardiac Output (ml●min⁻¹)	50.4 ±2.2	45.7 ±1.9	41.6 ±2.2	38.5 ±3.1^*
Coronary Flow (ml●min⁻¹)	26.5 ±2.8	23.9 ±0.5	22.3 ±0.7	20.8 ±1.5
Cardiac Work (joules●min^− 1●g dry weight^− 1)	2.1 ±0.1	1.9 ±0.1	1.6 ±0.1^*	1.4 ±0.2^*

Cardiac function was measured in isolated working hearts from Dahl salt-sensitive rats fed a low salt diet, 0.3% NaCl (Control), or a high salt diet, 8% NaCl, for 3, 6, or 9 weeks. n = 3–5 * p < 0.05 compared to Control. Values shown as mean ±SEM

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