Fig. 1
From: Erythropoiesis: insights into pathophysiology and treatments in 2017
Overview of erythropoiesis, from the hematopoietic stem cell (HSC) to the red blood cell (RBC). Erythropoiesis takes place in the bone marrow, and erythroblastic islands are niches for erythropoiesis from the CFU-E to the reticulocyte state. Then the reticulocyte reaches the blood stream where it achieves its maturation by losing its internal organelles, remodeling its plasma membrane and finally becomes a RBC