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Table 2 The target genes of miR-296 and its roles in atherosclerosis

From: MicroRNA-296: a promising target in the pathogenesis of atherosclerosis?

Target gene Pathways Function Potential effect in As Ref.
HGS PDGFR-β,VEGFR2 pro-angiogenesis (Würdinger et al. 2008)
? Dll4/Notch pro-angiogenesis (Feng et al. 2015)
NUMBL NF-κB pro-inflammatory ((Zhai et al. 2016); (Vaira et al. 2013))
IKBKE NLRP3 pro-inflammatory ((Robson et al. 2012); (Patel et al. 2015))
SOCS-2 M1 macrophage polarization pro-inflammatory ((Spence et al. 2013); (Lee et al. 2016))
Scrib M1 macrophage polarization pro-inflammatory ((Zheng et al. 2016); (Vaira et al. 2012))
Scrib ROS pro-inflammatory ((Zheng et al. 2016); (Vaira et al. 2012))
ICAM-1 directly anti-adhesion (Liu et al. 2013)
CX3CR1 directly anti-adhesion ((Wouters et al. 2017); (Luo and Lin 2016))
MDR1 directly intestinal cholesterol reabsorption ((Tous et al. 2005); (Hong et al. 2010))
WNK4 directly hypertension ((Takahashi et al. 2017); (Mao et al. 2010); (Li et al. 2011))
p21WAF1 directly proliferation ((Khanna 2009); (Yang et al. 1996); (Yoon et al. 2011))
p53 p21WAF1 proliferation ((Guevara et al. 1999); (Yoon et al. 2011))
p27 directly proliferation ((Hong et al. 2010); (Diez-Juan and Andres 2001))
PTEN directly proliferation ((Yuan et al. 2012); (Li et al. 2009); (Chen et al. 2004); (Huang and Kontos 2002); (Kakizaki et al. 2017))
NGFR directly anti-apoptosis ((Chaldakov et al. 2001); (Wang et al. 2000); (Lee et al. 2016))
Caspase-8 directly anti-apoptosis (Lee et al. 2016)
  1. ↑, stimulatory effect; ↓, inhibitory effect; As, atherosclerosis