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Table 2 The target genes of miR-296 and its roles in atherosclerosis

From: MicroRNA-296: a promising target in the pathogenesis of atherosclerosis?

Target gene

Pathways

Function

Potential effect in As

Ref.

HGS

PDGFR-β,VEGFR2

pro-angiogenesis

↑

(Würdinger et al. 2008)

?

Dll4/Notch

pro-angiogenesis

↑

(Feng et al. 2015)

NUMBL

NF-κB

pro-inflammatory

↑

((Zhai et al. 2016); (Vaira et al. 2013))

IKBKE

NLRP3

pro-inflammatory

↑

((Robson et al. 2012); (Patel et al. 2015))

SOCS-2

M1 macrophage polarization

pro-inflammatory

↑

((Spence et al. 2013); (Lee et al. 2016))

Scrib

M1 macrophage polarization

pro-inflammatory

↑

((Zheng et al. 2016); (Vaira et al. 2012))

Scrib

ROS

pro-inflammatory

↑

((Zheng et al. 2016); (Vaira et al. 2012))

ICAM-1

directly

anti-adhesion

↓

(Liu et al. 2013)

CX3CR1

directly

anti-adhesion

↓

((Wouters et al. 2017); (Luo and Lin 2016))

MDR1

directly

intestinal cholesterol reabsorption

↑

((Tous et al. 2005); (Hong et al. 2010))

WNK4

directly

hypertension

↓

((Takahashi et al. 2017); (Mao et al. 2010); (Li et al. 2011))

p21WAF1

directly

proliferation

↑

((Khanna 2009); (Yang et al. 1996); (Yoon et al. 2011))

p53

p21WAF1

proliferation

↑

((Guevara et al. 1999); (Yoon et al. 2011))

p27

directly

proliferation

↑

((Hong et al. 2010); (Diez-Juan and Andres 2001))

PTEN

directly

proliferation

↑

((Yuan et al. 2012); (Li et al. 2009); (Chen et al. 2004); (Huang and Kontos 2002); (Kakizaki et al. 2017))

NGFR

directly

anti-apoptosis

↑

((Chaldakov et al. 2001); (Wang et al. 2000); (Lee et al. 2016))

Caspase-8

directly

anti-apoptosis

↑

(Lee et al. 2016)

  1. ↑, stimulatory effect; ↓, inhibitory effect; As, atherosclerosis