From: MicroRNA-296: a promising target in the pathogenesis of atherosclerosis?
Target gene | Pathways | Function | Potential effect in As | Ref. |
---|---|---|---|---|
HGS | PDGFR-β,VEGFR2 | pro-angiogenesis | ↑ | (Würdinger et al. 2008) |
? | Dll4/Notch | pro-angiogenesis | ↑ | (Feng et al. 2015) |
NUMBL | NF-κB | pro-inflammatory | ↑ | |
IKBKE | NLRP3 | pro-inflammatory | ↑ | |
SOCS-2 | M1 macrophage polarization | pro-inflammatory | ↑ | |
Scrib | M1 macrophage polarization | pro-inflammatory | ↑ | |
Scrib | ROS | pro-inflammatory | ↑ | |
ICAM-1 | directly | anti-adhesion | ↓ | (Liu et al. 2013) |
CX3CR1 | directly | anti-adhesion | ↓ | |
MDR1 | directly | intestinal cholesterol reabsorption | ↑ | |
WNK4 | directly | hypertension | ↓ | ((Takahashi et al. 2017); (Mao et al. 2010); (Li et al. 2011)) |
p21WAF1 | directly | proliferation | ↑ | |
p53 | p21WAF1 | proliferation | ↑ | |
p27 | directly | proliferation | ↑ | |
PTEN | directly | proliferation | ↑ | ((Yuan et al. 2012); (Li et al. 2009); (Chen et al. 2004); (Huang and Kontos 2002); (Kakizaki et al. 2017)) |
NGFR | directly | anti-apoptosis | ↑ | ((Chaldakov et al. 2001); (Wang et al. 2000); (Lee et al. 2016)) |
Caspase-8 | directly | anti-apoptosis | ↑ | (Lee et al. 2016) |