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Fig. 4 | Molecular Medicine

Fig. 4

From: RETRACTED ARTICLE: Effects of CREB1 gene silencing on cognitive dysfunction by mediating PKA-CREB signaling pathway in mice with vascular dementia

Fig. 4

Decreased positive expression rate of CREB1 and increased Cleaved Caspase-3 in the hippocampal CA1 area of mice injected with shCREB1–1 or/and H89, Notes: A, the immunohistochemical staining results of CREB1 in each group (× 200); B, the histogram of the CREB1 average OD; C, the immunohistochemical staining results of Cleaved Caspase-3 in each group (× 200); D, the histogram of the Cleaved Caspase-3 average OD; *, p < 0.05, compared with the normal group; #, p < 0.05, compared with the VD group; CREB1, cyclic adenosine monophosphate responsive element-binding protein 1; CA1, cornu ammonis 1; VD, vascular dementia; OD, optical density

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Molecular Medicine

ISSN: 1528-3658