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Fig. 3 | Molecular Medicine

Fig. 3

From: Ligation of free HMGB1 to TLR2 in the absence of ligand is negatively regulated by the C-terminal tail domain

Fig. 3

HMGB1 enhances TLR2 responses to peptidoglycan. PBMCs were isolated from healthy controls and stimulated with HMGB1 or Δ30 alone or in complex with peptidoglycan (PGN) at the indicated concentrations. Supernatants were collected after 24 h and IL-6 levels were measured by ELISA. a) Representative cytokine levels from 1 healthy control and b) Fold change in IL-6 level compared to the control group (IL-6 release with HMGB1 alone + IL-6 release with PGN alone). n = 5 donors

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Molecular Medicine

ISSN: 1528-3658