Discovery set | Replication set | ||||||||||||||||||
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Gene1 | Chr1 | Gene2 | Chr2 | SNP1 (Risk allele) | Position (hg19,bp) | MAF | SNP2 (Risk allele) | Position (hg19,bp) | MAF | WZ P-value | OR (95% CI) | SNP1 (Risk allele) | Position (hg19,bp) | MAF | SNP2 (Risk allele) | Position (hg19,bp) | MAF | WZ P value | OR (95% CI) |
TNC | 9q33.1 | CRYL1 | 13q12.11 | rs10118040 (T) | 117,879,414 | 0.40 | rs7337130 (C) | 21,021,343 | 0.31 | 6.91E-11 | 2.64 (1.91–3.65) | rs1330368 (A) | 117,821,026 | 0.48 | rs7337231 (G) | 20,896,618 | 0.49 | 2.48E-08 | 1.05 (0.96–1.14) |
SETBP1 | 18q12.3 | PREX1 | 20q13.13 | rs12959213 (C) | 42,769,020 | 0.41 | rs6066791 (T) | 47,251,687 | 0.26 | 7.07E-11 | 2.39 (1.75–3.25) | rs11082429 (G) | 42,743,790 | 0.44 | rs170536 (A) | 46,878,722 | 0.32 | 4.25E-08 | 1.01 (0.93–1.09) |
SETBP1 | 18q12.3 | PREX1 | 20q13.13 | rs12959213 (C) | 42,769,020 | 0.41 | rs6066791 (T) | 47,251,687 | 0.26 | 7.07E-11 | 2.39 (1.75–3.25) | rs1376230 (T) | 42,703,052 | 0.35 | rs6063251 (C) | 47,015,157 | 0.43 | 6.37E-07 | 1.03 (0.94–1.11) |
ERBB4 | 2q34 | RORA | 15q22.2 | rs1546717 (G) | 212,902,339 | 0.10 | rs1159814 (A) | 61,431,996 | 0.41 | 9.07E-11 | 5.03 (2.89–8.77) | rs6745249 (G) | 213,130,571 | 0.48 | rs974065 (A) | 60,952,440 | 0.34 | 1.06E-10 | 1.13 (1.04–1.22) |
PARK2 | 6q26 | C14orf177 | 14q32.2 | rs6455744 (T) | 162,060,468 | 0.38 | rs7359146 (C) | 99,084,602 | 0.14 | 1.12E-10 | 2.92 (1.96–4.33) | rs6927285 (G) | 162,010,329 | 0.43 | rs8022922 (A) | 98,987,292 | 0.44 | 1.23E-14 | 1.06 (0.98–1.14) |
ETNK1 | 12p12.1 | TMC2 | 20p13 | rs2467112 (C) | 23,071,644 | 0.19 | rs1028441 (T) | 2,600,186 | 0.24 | 1.20E-10 | 3.24 (2.12–4.95) | rs7313039 (C) | 23,091,130 | 0.47 | rs6050256 (T) | 2,554,907 | 0.48 | 2.04E-07 | 1.05 (0.97–1.14) |
aLOC646784 / HFM1 | 1p22.2 | LOC647259 | 13q21.1 | rs674135 (G) | 91,675,675 | 0.26 | rs4146191 (A) | 62,872,965 | 0.47 | 1.44E-10 | 2.61 (1.89–3.60) | rs7416823 (T) | 157,386,394 | 0.31 | rs428328 (C) | 63,110,606 | 0.41 | 2.24E-09 | 1.05 (0.96–1.13) |
ERBB4 | 2q34 | PTPRD | 9p23 | rs1437919 (A) | 212,110,840 | 0.23 | rs10978043 (G) | 9,860,402 | 0.19 | 2.64E-10 | 3.38 (2.19–5.22) | rs6747637 (G) | 212,406,789 | 0.45 | rs4427223 (A) | 10,663,815 | 0.48 | 7.35E-14 | 1.01 (0.93–1.09) |
AUTS2 | 7p11.22 | HS6ST3 | 13q32.1 | rs1011780 (A) | 70,124,648 | 0.28 | rs9556582 (G) | 97,040,531 | 0.46 | 2.68E-10 | 2.40 (1.75–3.29) | rs10267303 (T) | 70,082,913 | 0.47 | rs12876541 (C) | 97,304,003 | 0.44 | 3.33E-08 | 1.06 (0.97–1.14) |
SETBP1 | 18q12.3 | PREX1 | 20q13.13 | rs12959213 (C) | 42,769,020 | 0.41 | rs4810836 (T) | 47,228,931 | 0.25 | 3.04E-10 | 2.40 (1.75–3.25) | rs11082429 (G) | 42,743,790 | 0.44 | rs170536 (A) | 46,878,722 | 0.32 | 4.25E-08 | 0.98 (0.90–1.06) |
SETBP1 | 18q12.3 | PREX1 | 20q13.13 | rs12959213 (C) | 42,769,020 | 0.41 | rs4810836 (T) | 47,228,931 | 0.25 | 3.04E-10 | 2.40 (1.75–3.25) | rs1376230 (T) | 42,703,052 | 0.35 | rs6063251 (C) | 47,015,157 | 0.43 | 6.37E-07 | 0.97 (0.89–1.05) |
CNTN4 | 3p26.3 | FAM19A1 | 3p14.1 | rs2619566 (C) | 2,624,938 | 0.12 | rs1032376 (A) | 68,317,975 | 0.19 | 3.28E-10 | 4.66 (2.71–8.02) | rs1499133 (C) | 2,952,214 | 0.41 | rs7610023 (T) | 68,123,731 | 0.40 | 4.14E-09 | 1.05 (0.97–1.14) |
CNTN4 | 3p26.3 | FAM19A1 | 3p14.1 | rs2619566 (G) | 2,624,938 | 0.12 | rs1032376 (A) | 68,317,975 | 0.19 | 3.28E-10 | 4.66 (2.71–8.02) | rs1178491 (G) | 2,342,825 | 0.36 | rs6549098 (A) | 68,323,280 | 0.40 | 2.83E-08 | 0.98 (0.90–1.06) |
TNC | 9q33.1 | CRYL1 | 9q33.1 | rs2071520 (T) | 117,880,792 | 0.32 | rs7337130 (C) | 21,021,343 | 0.31 | 3.50E-10 | 2.80 (1.99–3.15) | rs1330368 (A) | 117,821,026 | 0.48 | rs7337231 (G) | 20,896,618 | 0.49 | 2.48E-08 | 0.96 (0.89–1.04) |
CSMD1 | 8p23.2 | LOC392301 | 9q13 | rs1700112 (G) | 4,097,418 | 0.41 | rs410684 (A) | 31,673,588 | 0.42 | 3.84E-10 | 2.16 (1.62–2.87) | rs2740939 (C) | 3,872,513 | 0.48 | rs7853053 (T) | 32,211,402 | 0.49 | 2.04E-16 | 1.04 (0.95–1.12) |
CSMD1 | 8p23.2 | LOC392301 | 9q13 | rs1700112 (G) | 4,097,418 | 0.41 | rs410684 (A) | 31,673,588 | 0.42 | 3.84E-10 | 2.16 (1.62–2.87) | rs2740929 (C) | 3,879,918 | 0.49 | rs7853053 (T) | 32,211,402 | 0.49 | 3.81E-10 | 1.04 (0.95–1.12) |
ERBB4 | 2q34 | LOC729802 | 9p23 | rs1437919 (A) | 212,110,840 | 0.23 | rs7851513 (G) | 9,842,176 | 0.19 | 3.92E-10 | 3.10 (2.05–4.69) | rs6747637 (G) | 212,406,789 | 0.45 | rs4427223 (A) | 10,663,815 | 0.48 | 7.35E-14 | 0.92 (0.85–0.99) |
KHDRBS3 | 8q24.23 | KSR2 | 12q24.23 | rs4909494 (C) | 136,646,548 | 0.46 | rs10774941 (T) | 118,037,655 | 0.27 | 4.22E-10 | 2.51 (1.83–3.45) | rs16905387 (G) | 136,539,132 | 0.42 | rs7972142 (A) | 118,211,046 | 0.44 | 3.97E-13 | 1.05 (0.96–1.13) |
SETBP1 | 18q12.3 | PREX1 | 20q13.13 | rs12959213 (C) | 42,769,020 | 0.41 | rs6095212 (T) | 47,233,383 | 0.25 | 4.25E-10 | 2.39 (1.75–3.25) | rs11082429 (G) | 42,743,790 | 0.44 | rs170536 (A) | 46,878,722 | 0.32 | 4.25E-08 | 1.04 (0.96–1.12) |
SETBP1 | 18q12.3 | PREX1 | 20q13.13 | rs12959213 (C) | 42,769,020 | 0.41 | rs6095212 (T) | 47,233,383 | 0.25 | 4.25E-10 | 2.39 (1.75–3.25) | rs1376230 (T) | 42,703,052 | 0.35 | rs6063251 (C) | 47,015,157 | 0.43 | 6.37E-07 | 1.03 (0.95–1.11) |
MAN1A1 | 6q22.31 | FRMD4A | 10p13 | rs808034 (A) | 119,467,743 | 0.39 | rs789761 (C) | 14,137,678 | 0.48 | 4.72E-10 | 0.46 (0.34–0.61) | rs1295392 (G) | 119,676,177 | 0.45 | rs751498 (A) | 13,929,130 | 0.47 | 1.25E-09 | 1.05 (0.96–1.14) |
BNC2 | 9p22.3 | CDH13 | 16q23.3 | rs7867771 (T) | 16,314,909 | 0.28 | rs11149564 (C) | 83,441,027 | 0.44 | 4.82E-10 | 2.20 (1.62–3.00) | rs1415471 (A) | 16,656,653 | 0.44 | rs7194615 (G) | 82,769,498 | 0.44 | 1.07E-08 | 1.02 (0.94–1.09) |
DAOA | 13q33.2 | TOM1L1 | 17q22 | rs5012127 (G) | 105,119,100 | 0.17 | rs4793773 (A) | 52,646,414 | 0.27 | 4.89E-10 | 2.81 (1.88–4.02) | rs3015345 (A) | 105,860,621 | 0.45 | rs8070668 (G) | 52,991,636 | 0.38 | 6.06E-10 | 1.05 (0.97–1.14) |