Fig. 6
From: The interplay between AR, EGF receptor and MMP-9 signaling pathways in invasive prostate cancer
The effect of inhibition of the PI3K/AKT/AR axis on the expression of AR, MMP-9 and EGFR in PC-3 cells. a Immunoblot analysis on the expression of AR in PC-3 cells that were transfected with pCMV control or pCMV-AR vectors followed by treatment with PIP5K1α/AKT inhibitor ISA-2011B. b Immunoblot analysis on the expression of MMP-9 in PC-3 cells that were transfected with pCMV control vector followed by treatment with ISA-2011B. c Immunoblot analysis on the expression of MMP-9 in PC-3 cells that were transfected with pCMV-AR vector followed by treatment with ISA-2011B. d Immunoblot analysis on the expression of EGFR in PC-3 cells that were transfected with pCMV control or pCMV-AR vectors followed by treatment with ISA-2011B. Data presented is the average of at least two independent experiments (±SD). p < 0.05 is indicated by “*”, p ≤ 0.01 is indicated by “**”, p ≤ 0.001 is indicated by “***”