Fig. 3

CircCEP128 serves as a sponge of miR-145-5p and indirectly targets at SOX11. a and b Binding sites of miR-145-5p in circCEP128/SOX11 3’UTR (Up). Luciferase reporter assay revealed that miR-145-5p was able to reduce the luciferase intensity more than 40% by targeting at wild type RNAs (WT, Down). ^**P < 0.01, compared with the group with only vector. c and d RNA pull-down assays indicated the physical interactions between circCEP128 and miR-145-5p or between miR-145-5p and SOX11