Changes in expression profiles of internal jugular vein wall and plasma protein levels in multiple sclerosis

Table 2 Protein plasma levels in jugular vein (1st MS population) and in peripheral vein (1st MS population and healthy subjects)

PROTEINS	MS/CCSVI JUGULAR PLASMA (n = 17)	P*	MS/CCSVI PERIPHERAL PLASMA (n = 17)	P ^#	HEALTHY PERIPHERAL PLASMA (n = 34)	mRNA PROFILING
ANGPT1	2.6 ± 0.90	0.016	3.6 ± 1.7	0.02	6.2 ± 2.8	↓
CCL13	87.3 ± 32.8	0.22	79.6 ± 23.2	0.33	89.7 ± 39.6	↓
CCL18	27.2 ± 9.3	0.048	30.4 ± 11.1	0.30	34.7 ± 15.5	↓
CD86	183.9 ± 50.7	0.004	221.3 ± 66.4	0.7	214.2 ± 62.4^§	↑
NCAM1	138.2 ± 57	0.005	149.9 ± 58.3	0.08	123.5 ± 44.2	↑
SELL	451.4 ± 97.5	0.002	522.7 ± 117.2	0.16	584.4 ± 158.8	↑
VAP1	223.8 ± 45.6	0.06	241.7 ± 43.5	0.09	272.0 ± 65.8	↓

Proteins: ANGPT1 angiopoietin 1, CCL13 chemokine ligand 13, CCL18 chemokine ligand 18, CD86 cluster of differentiation 86, NCAM1 neural cell adhesion molecule 1, SELL selectin L, VAP1(AOC3) vascular adhesion protein 1(amine oxidase copper containing 3). Protein concentrations are reported in ng/ml, except for CD86 (U/ml). All values are expressed as mean ± standard deviation. Arrows indicate up (↑) or down (↓) mRNA regulation in MS vs non-MS jugular wall. *P values from paired t-test (MS jugular plasma vs MS peripheral plasma). ^#P value from t-test on peripheral plasma (MS patients vs healthy subjects). § evaluated in 28 plasma controls

ISSN: 1528-3658