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Fig. 1 | Molecular Medicine

Fig. 1

From: Reversal of angiotensin ll-induced β-cell dedifferentiation via inhibition of NF-κb signaling

Fig. 1

RAS inhibition reverses glucotoxicity-induced compromised β-cell identity. Pancreatic β cell lines were cultured with increasing concentrations of glucose in the presence or absence of irbesartan (IRB, 10 μmol/L) for 24 h. Performing (a, b) a GSIS assay to determine (c, d) the stimulatory index in Min6 cells and INS-1 cells. qRT-PCR analyses for markers of (e-h) β cell identity genes (Ins1, Pdx1), and (i-l) progenitor like cells markers (Ngn3, Oct4) in β cells. Data are presented as the mean ± SEM of three independent experiments (n = 6). *p < 0.05, **p < 0.01, ***p < 0.001, one-way ANOVA

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