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Fig. 10 | Molecular Medicine

Fig. 10

From: Over-expressed microRNA-181a reduces glomerular sclerosis and renal tubular epithelial injury in rats with chronic kidney disease via down-regulation of the TLR/NF-κB pathway by binding to CRY1

Fig. 10

Western blot reveals that up-regulated miR-181a or down-regulated CRY1 inhibits the activation of the TLR/NF-κB pathway by decreasing the protein expression of TLR/NF-κB pathway-related genes. Notes: Panel a, bar graph of protein expression of CRY1, TLR2, TLR4, and NF-κB in each group; Panel b, protein bands of CRY1, TLR2, TLR4, and NF-κB in each group; *, p < 0.05 vs. the normal group; #, p < 0.05 vs. the blank and NC groups; the data are presented as the mean ± standard deviation, analyzed by one-way ANOVA; the experiment was independently repeated three times; NC, negative control; miR-181a, microRNA-181a; CRY1, cryptochrome 1; TLR2, toll-like receptor 2; TLR4, toll-like receptor 4; NF-κB, nuclear factor-kappa B; CKD, chronic kidney disease

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Molecular Medicine

ISSN: 1528-3658