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Fig. 8 | Molecular Medicine

Fig. 8

From: Over-expressed microRNA-181a reduces glomerular sclerosis and renal tubular epithelial injury in rats with chronic kidney disease via down-regulation of the TLR/NF-κB pathway by binding to CRY1

Fig. 8

A targeting/regulatory relationship between miR-181a and CRY1 is identified by the target prediction program and determination of luciferase activity. Notes: Panel a, predicted binding sites for miR-181a in the CRY1 3’UTR; Panel b, luciferase activity of cells transfected with CRY1–3’UTR-WT and CRY1–3’UTR-MUT; *, p < 0.05 vs. the NC group; the data are presented as the mean ± standard deviation, analyzed by t-test; the experiment was independently repeated three times; miR-181a, microRNA-181a; CRY1, cryptochrome 1; NC, negative control; UTR, untranslated region; WT, wild-type; MUT, mutant

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Molecular Medicine

ISSN: 1528-3658