Over-expressed microRNA-181a reduces glomerular sclerosis and renal tubular epithelial injury in rats with chronic kidney disease via down-regulation of the TLR/NF-κB pathway by binding to CRY1

Table 2 Upregulation of miR-181a or downregulation of CRY1 decreases the contents of urine albumin, uric acid, urea of CKD rats (n = 10)

Group	Urea (mmol/L)	Uric acid (μmol/L)	Albumin (g/L)
Normal	4.53 ± 0.75	152.32 ± 23.11	34.24 ± 5.12
Blank	48.16 ± 7.54^*	256.71 ± 33.28^*	20.97 ± 3.24^*
NC	47.28 ± 7.23^*	251.37 ± 32.14^*	20.07 ± 3.13^*
MiR-181a mimic	14.76 ± 2.31^*#	193.48 ± 27.12^*#	26.14 ± 4.12^*#
MiR-181a inhibitor	67.82 ± 10.09^*#	303.45 ± 33.23^*#	13.92 ± 2.34^*#
si-CRY1	14.24 ± 2.13^*#	201.64 ± 25.96^*#	28.18 ± 4.31^*#
MiR-181a inhibitor + si-CRY1	46.82 ± 7.22^*	248.39 ± 31.42^*	23.26 ± 3.56^*

Note: ^*, p < 0.05 vs. the normal group; ^#, p < 0.05 vs. the blank and NC groups; the data are presented as mean ± standard deviation and analyzed by one-way ANOVA.; the experiment was independently repeated three times
NC negative control, miR-181a microRNA-181a, CRY1 cryptochrome 1, CKD chronic kidney disease

ISSN: 1528-3658