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Table 3 Comparing different formats of bispecific antibodies

From: Bi-specific and tri-specific antibodies- the next big thing in solid tumor therapeutics

Antibody format



IgG- like bispecifc antibodies

Longer half life

Fc region more immunogenic

Fc domain facilitates efficient purification

Fc domain able to trigger antibody dependent cell mediated toxicity, complement dependent cell mediated toxicity

Bispecific Antibody Fragments

High tumor specificity

Small size make them prone to elimination i.e. shorter half-life

Good tissue penetration

Small formats can allow close contacts between effector and target cells forming efficient immune synapses not requiring co-stimulatory molecules

Easy to manufacture