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Table 3 Comparing different formats of bispecific antibodies

From: Bi-specific and tri-specific antibodies- the next big thing in solid tumor therapeutics

Antibody format Advantages Disadvantages
IgG- like bispecifc antibodies Longer half life Fc region more immunogenic
Fc domain facilitates efficient purification
Fc domain able to trigger antibody dependent cell mediated toxicity, complement dependent cell mediated toxicity
Bispecific Antibody Fragments High tumor specificity Small size make them prone to elimination i.e. shorter half-life
Good tissue penetration
Small formats can allow close contacts between effector and target cells forming efficient immune synapses not requiring co-stimulatory molecules
Easy to manufacture