From: Bi-specific and tri-specific antibodies- the next big thing in solid tumor therapeutics
Antibody format | Advantages | Disadvantages |
---|---|---|
IgG- like bispecifc antibodies | Longer half life | Fc region more immunogenic |
Fc domain facilitates efficient purification | ||
Fc domain able to trigger antibody dependent cell mediated toxicity, complement dependent cell mediated toxicity | ||
Bispecific Antibody Fragments | High tumor specificity | Small size make them prone to elimination i.e. shorter half-life |
Good tissue penetration | ||
Small formats can allow close contacts between effector and target cells forming efficient immune synapses not requiring co-stimulatory molecules | ||
Easy to manufacture |