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Fig. 7 | Molecular Medicine

Fig. 7

From: Protective role of down-regulated microRNA-31 on intestinal barrier dysfunction through inhibition of NF-κB/HIF-1α pathway by binding to HMOX1 in rats with sepsis

Fig. 7

MiR-31 regulated expression of the NF-κB/HIF-1α pathway related genes by inhibiting HMOX1. a-b RT-qPCR detected that the mRNA levels of NF-κB, HIF-1α, HMOX1, IκB, ZO-1, and Occludin in the ileal tissue of the rats were affected by miR-31 through HMOX1; (c-d), Western blot analysis detected that protein levels of IκB, p-IκB, ZO-1, HMOX1, HIF-1α, NF-κB, and Occludin in the ileal tissue of the rats were regulated by miR-31 via HMOX1; *, p < 0.05, vs. the sham group; #, p < 0.05, vs. the sepsis group; NC negative control

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Molecular Medicine

ISSN: 1528-3658