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Fig. 2 | Molecular Medicine

Fig. 2

From: Suppressed microRNA-96 inhibits iNOS expression and dopaminergic neuron apoptosis through inactivating the MAPK signaling pathway by targeting CACNG5 in mice with Parkinson’s disease

Fig. 2

miR-96 is predicted to regulate the MAPK signaling pathway via CACNG5. a prediction of target relationship between miR-96 and CACNG5 promoter region; b the effect of miR-96 on WT-CACNG5 and Mut-CACNG5 luciferase reporter plasmid; c the effect of CACNG5 on the expression of iNOS protein; d and e, effect of miR-96 on the expression of iNOS protein. *, P < 0.05 compared with the NC group. The test was repeated three times independently, and the non-paired t-test was used for comparison between the two groups; the one-way ANOVA analysis was used for comparison among multiple groups. miR-96, microRNA-96; CACNG5, calcium voltage-gated channel auxiliary subunit gamma 5; Wt, wild-type; Mut, mutant; NC, negative control

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Molecular Medicine

ISSN: 1528-3658