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Fig. 7 | Molecular Medicine

Fig. 7

From: Suppressed microRNA-96 inhibits iNOS expression and dopaminergic neuron apoptosis through inactivating the MAPK signaling pathway by targeting CACNG5 in mice with Parkinson’s disease

Fig. 7

Down-regulation of miR-96 leads to the inhibition of the MAPK signaling pathway through the up-regulation of CACNG5. a miR-96 expression and mRNA expression of CACNG5, p38MAPK and c-Fos evaluated by RT-qPCR among seven groups; b protein expression of CACNG5, p38MAPK, c-Fos, and p-p38MAPK evaluated by Western blot analysis among seven groups; c protein bands of CACNG5, p38MAPK, c-Fos, and p-p38MAPK; GAPDH used as a internal reference. The test was repeated three times independently, and the one-way ANOVA analysis was used for comparison among multiple groups (n = 10 in each group). *, P < 0.05 compared with the normal group, #, P < 0.05 compared with the PD and NC groups; miR-96, microRNA-96; CACNG5, calcium voltage-gated channel auxiliary subunit gamma 5; p38MAPK, p38 mitogen-activated protein kinase; RT-qPCR, reverse transcription quantitative polymerase chain reaction; PD, Parkinson’ disease; NC, negative control

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