Fig. 1

Major RAGE isoforms. The full length receptor includes one cytoplasmic domain involved in signal transduction, and three extracellular domains comprised of two c-type domains and one v-type domain. The N-truncated isoform lacks AGE binding properties and is not activated by ligand binding. Dominant negative RAGE serves as a cell-bound decoy receptor. It lacks a cytosolic domain and is not involved in signal transduction. Soluble RAGE consists of the complete extracellular domain, produced either via alternative splicing and directly secreted from the cell, or as a by-product of cleavage of full length RAGE by extracellular proteases. Copied with permission from Lee EJ, Park JH, Genomics and Informatics 2013