Total serum cholinesterase activity predicts hemodynamic changes during exercise and associates with cardiac troponin detection in a sex-dependent manner

Table 1 Population Characteristics by Sex

Characteristic	Men	Women	p - value
N	1153 (75%)	373 (25%)
Age, years	50 (11)	47 (12)	0.001
BMI, Kg/m²	27 (4)	25 (5)	< 0.001
Resting Pulse, beats/min	69 (14)	74 (11)	0.002
Systolic BP, mmHg	130 (16)	119 (20)	< 0.001
Diastolic BP, mmHg	80 (34)	73 (12)	0.001
Peak systolic BP, mmHg	173 (23)	156 (23)	< 0.001
Peak diastolic BP, mmHg	72 (13)	70 (13)	0.091
METs	12 (2)	10 (6)	< 0.001
Cholinergic status, normalized nmol/min/ml	1471 (342)	1370 (291)	< 0.001
hs-cTnT, ng/L	5 [3^a,7]	3.0 [3^a,4]	< 0.001
Fasting glucose, mg/dl	89 (14)	84 (9)	< 0.001
HbA1c, %	5.4 [5.2, 5.7]	5.4 [5.1, 5.6]	0.054
T-C, mg/dl	186 (33)	192 (33)	0.004
HDL-C, mg/dl	47 (12)	61 (15)	< 0.001
LDL-C, mg/dl	115 (28)	111 (28)	0.032
TG, mg/dl	121 (65)	100 (49)	< 0.001
eGFR, mL/min/1.73m²	94 (14)	100 (15)	< 0.001
UACR, mg/g	2 [1, 4]	3 [2, 7]	< 0.001
hs-CRP, mg/l	2 (2.9)	2.7 (3.7)	< 0.001
Diabetes diagnosis (%)	62 (7)	8 (3)	0.016
Hypertension (%)	182 (17)	32 (9)	< 0.001
IHD diagnosis (%)	53 (6)	13 (5)	0.470
Use of antihypertensive- medication (%)	134 (12)	17 (5)	< 0.001
Hyperlipidemia (%)	97 (9)	25 (7)	0.307

BP blood pressure, BMI body mass index, METs Metabolic equivalents; hs-cTnT high sensitive cardiac troponin T, HbA1c Hemoglobin A1C, T-C total cholesterol, HDL-C high density lipoprotein cholesterol, LDL-C low density lipoprotein cholesterol, TG triglycerides, eGFR estimated glomerular filtration rate, UACR urinary albumin/creatinine ratio, hs-CRP high sensitive C- reactive protein, IHD ischemic heart disease. Values are mean (SD) or median [interquartile range]
^a Equivalent to non-detectable hs-cTnT (below detection level of 5 ng/L), as described in the Methods section

ISSN: 1528-3658