Fig. 2
From: TRIF signaling is required for caspase-11-dependent immune responses and lethality in sepsis
TRIF is required for caspase-11-dependent organ injury and lethality in endotoxemia. a Histology of the lungs from mice of indicated genotypes (n = 5) following intraperitoneal injection with either 10 mg/kg LPS or saline. Lungs were collected 8 h after LPS injection and then stained with H&E. b-c The serum alanine aminotransferase (ALT) and creatinine (Cre) levels from mice of indicated genotypes following intraperitoneal injection with either 10 mg/kg LPS or saline. Serum samples were collected 8 h after LPS injection. d Kaplan Meier survival curves for the indicated genotypes mouse strains subjected to 40 mg/kg LPS injection. *P<0.05; **P<0.01; ***P<0.001 (Student’s t-test and log-rank test for survival). Graphs show the mean ± SD. Data are representative of at least three independent experiments