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Fig. 6 | Molecular Medicine

Fig. 6

From: TRIF signaling is required for caspase-11-dependent immune responses and lethality in sepsis

Fig. 6

Type 1 IFNs-GBPs pathway is critical for caspase-11-dependent immune responses, organ injury and lethality in sepsis. a-b Serum IL-1α and IL-1β levels from mice of indicated genotypes subjected to either CLP or sham operation. c H&E staining of the lungs from mice of indicated genotypes (n = 5) subjected to either CLP or sham operation. d-e The serum alanine aminotransferase (ALT) and creatinine (Cre) levels from mice of indicated genotypes were subjected to either CLP or sham operation. f Kaplan Meier survival curves for the indicated genotypes subjected to either CLP or sham operation.*P<0.05; **P<0.01; ***P<0.001 (Student’s t-test and log-rank test for survival). Graphs show the mean ± SD. Data are representative of at least three independent experiments

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