Fig. 4

Hepatic and muscle glycogen content and alteration of hepatic GSK3 in SUR1^−/− and wild-type rats. SUR1^−/− rats showed increased hepatic (A and B) and muscle (C and D) glycogen which were stained as purple particles and arrow heads were pointing at, and the PGSK3/GSK3 ratio (E and F) in the liver was significantly increased in SUR1^−/− rats. a: SUR1^−/− male; b: SUR1^−/− female; c: wild-type male; d: wild-type female. The values denote the means ± SEM. *: P < 0.05. Images of PAS staining for glycogen were taken at × 200 magnification; a small part was magnified to × 400 and is shown on the top left corner of each picture