Fig. 3
From: Loss of intestinal sympathetic innervation elicits an innate immune driven colitis
Pre-treatment with norepinephrine or salbutamol altered the metabolic profile of lipopolysaccharide (LPS)-exposed bone marrow derived macrophages (BMDM). a, b Metabolic parameters (described in van den Bossche et al. (2015)) of BMDM after treatment with 100 ng/ml LPS for 18 h and pre-treatment with different concentrations of norepinephrine (a) or salbutamol (b) together with propranolol. Data is shown relative to BMDM not exposed to any treatment (control). c Maximum respiration of BMDM after treatment with 100 ng/ml LPS for 18 h and pre-treatment with different concentrations of norepinephrine or salbutamol together with propranolol. Data is shown relative to BMDM not exposed to any treatment (red dashed line). N = 6 mice. Data is expressed as mean and individual data points. We tested for statistical significant differences with an ANOVA and post-hoc Bonferroni correction. P-value < 0.05 was considered significant. * P-value < 0.05