Loss of intestinal sympathetic innervation elicits an innate immune driven colitis

Table 3 Histology score adapted from Read et al. (2001)

Score	0	1	2	3	4
Mono- and polymorphonuclear infiltrate	Normal	Increase in mucosa	Increase in mucosa and submucosa	Extending into mucosa, submucosa, tunica muscularis and/or serosa
Goblet cells	Normal, large amount	Depletion of < 10%	Depletion of 10–50%	Depletion of > 50%
Crypt loss	No crypt loss	< 10% crypt loss	10–50% crypt loss	> 50% crypt loss
Epithelial hyperplasia	Normal	Slight hyperplasia	2-3x increase of crypt length	>3x increase of crypt length
Ulcerations	No ulceration				Ulcerations
Crypt abscesses	No abscesses				Crypt abscesses

ISSN: 1528-3658