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Table 2 Biophysical parameters of Nav1.2 wild-type and mutants

From: Further corroboration of distinct functional features in SCN2A variants causing intellectual disability or epileptic phenotypes

  Peak current density Voltage dep. of steady-state inactivation Voltage dep. of steady-state activation Recovery from inactivation 10–90% rise time Fast decay time constant
Mean peak amplitude (pA/pF) n V1/2 (mV) k n V1/2 (mV) k n τrec (ms) n t at 0 mV (ms) n τfast at 0 mV (ms) n
wild-type −54.24 ± 12.60 8 −63.53 ± 0.79 −6.91 ± 0.69 9 −23.87 ± 0.64 6.46 ± 0.57 9 7.02 ± 0.86 9 0.38 ± 0.05 9 0.58 ± 0.07 9
L1342P − 108.80 ± 23.20 9 −79.71 ± 1.18** − 8.30 ± 1.02 9 −39.07 ± 0.82** 7.25 ± 0.73 9 15.03 ± 2.18* 6 0.26 ± 0.03 9 0.51 ± 0.06 9
E1803G −53.48 ± 12.28 8 −60.90 ± 1.87 −12.35 ± 1.00** 8 −23.61 ± 0.88 7.38 ± 0.78 8 10.04 ± 1.91 7 0.48 ± 0.08 7 0.90 ± 0.11 7
L1563V −90.55 ± 20.97 6 −59.77 ± 1.21* −8.75 ± 1.07 6 −25.17 ± 0.61 5.37 ± 0.53 6 6.05 ± 1.27 6 0.40 ± 0.06 6 0.66 ± 0.08 6
  1. Values significantly different from wild-type are indicated as follows p < 0.05, p < 0.001