- Statistical analysis of data normalised by MAD was performed using Student’s t-test, and p-values are given. Statistically significant differences where pIgR−/− metabolite values were greater than B6 are highlighted in green, and decreases are highlighted in red. Statistically significant p-values are highlighted by *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001