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Fig. 6 | Molecular Medicine

Fig. 6

From: PGK1 facilities cisplatin chemoresistance by triggering HSP90/ERK pathway mediated DNA repair and methylation in endometrial endometrioid adenocarcinoma

Fig. 6

PGK1 facilitates chemoresistance to cisplatin through HSP90/ERK pathway. a-b. MTT assay was used to evaluate the effects of PGK1 overexpression or HSP90 ATPase inhibitor 17-AAG on chemoresistance to cisplatin in Ishikawa (a) and HEC1A (b) cell lines. Vector, empty vector; PGK1, plasmid for PGK1 overexpression; PGK1 + 17-AAG, plasmid for PGK1 overexpression supplemented with 17-AAG. c-d. MTT assay was used to evaluate the effects of PGK1 overexpression or ERK pathway inhibitor PD98059 on chemoresistance to cisplatin in Ishikawa (c) and HEC1A (D) cell lines. Vector, empty vector; PGK1, plasmid for PGK1 overexpression; PGK1+ PD98059, plasmid for PGK1 overexpression supplemented with PD98059. Data were shown as mean ± SD based on three independent experiments. *, P < 0.05, **, P < 0.01 compared with empty vector group or PGK1 overexpressed group respectively

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Molecular Medicine

ISSN: 1528-3658