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Table 2 Comparison of EGFR mutational status between plasma and post-TKI tissue samples

From: Tag-based next generation sequencing: a feasible and reliable assay for EGFR T790M mutation detection in circulating tumor DNA of non small cell lung cancer patients

Patient N. EGFR mutation in post-TKI Plasma EGFR mutation in post-TKI Tissues Tissue obtained by Tumor source
Sensitizing T790M Sensitizing T790M
2 exon 19 del pos exon 19 del pos needle biopsy pleura
18 exon 19 del pos exon 19 del pos cytology lymph node
34 exon 19 del pos exon 19 del pos needle biopsy lung
37 exon 19 del pos exon 19 del pos needle biopsy bronchus
14 exon 19 del neg a exon 19 del pos cytology pleural fluid
11 L858R neg L858R neg cytology lymph node
4 neg neg L858R neg cytology liquor
13 L858R neg L858R neg cytology pleural fluid
25 L858R pos L858R neg needle biopsy lung
28 exon 20 ins neg exon 20 ins neg needle biopsy lymph node
8 L858R neg L858R neg cytology lymph node
20 L858R neg L858R neg cytology bronchus/trachea
39 G719C/S768I pos G719C/S768I neg biopsy bronchus
42 exon 19 del neg exon 19 del neg cytology vertebral bone
40 exon 19 del neg exon 19 del neg needle biopsy lung
  1. del deletion, ins insertion, pos positive, neg negative
  2. adiscordant EGFR results between plasma and tissues are indicated in bold letters
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Molecular Medicine

ISSN: 1528-3658