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Table 2 Comparison of EGFR mutational status between plasma and post-TKI tissue samples

From: Tag-based next generation sequencing: a feasible and reliable assay for EGFR T790M mutation detection in circulating tumor DNA of non small cell lung cancer patients

Patient N.

EGFR mutation in post-TKI Plasma

EGFR mutation in post-TKI Tissues

Tissue obtained by

Tumor source

Sensitizing

T790M

Sensitizing

T790M

2

exon 19 del

pos

exon 19 del

pos

needle biopsy

pleura

18

exon 19 del

pos

exon 19 del

pos

cytology

lymph node

34

exon 19 del

pos

exon 19 del

pos

needle biopsy

lung

37

exon 19 del

pos

exon 19 del

pos

needle biopsy

bronchus

14

exon 19 del

neg a

exon 19 del

pos

cytology

pleural fluid

11

L858R

neg

L858R

neg

cytology

lymph node

4

neg

neg

L858R

neg

cytology

liquor

13

L858R

neg

L858R

neg

cytology

pleural fluid

25

L858R

pos

L858R

neg

needle biopsy

lung

28

exon 20 ins

neg

exon 20 ins

neg

needle biopsy

lymph node

8

L858R

neg

L858R

neg

cytology

lymph node

20

L858R

neg

L858R

neg

cytology

bronchus/trachea

39

G719C/S768I

pos

G719C/S768I

neg

biopsy

bronchus

42

exon 19 del

neg

exon 19 del

neg

cytology

vertebral bone

40

exon 19 del

neg

exon 19 del

neg

needle biopsy

lung

  1. del deletion, ins insertion, pos positive, neg negative
  2. adiscordant EGFR results between plasma and tissues are indicated in bold letters