Skip to main content

Advertisement

Fig. 2 | Molecular Medicine

Fig. 2

From: Validation of impaired Transient Receptor Potential Melastatin 3 ion channel activity in natural killer cells from Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis patients

Fig. 2

TRPM3 activity after successive applications of PregS and nifedipine. Data were obtained under whole-cell patch clamp conditions. a. A representative time-series of current amplitude at + 100 mV and − 100 mV showing the effect of 100 μΜ PregS and 100 μM nifedipine on ionic currents in isolated NK cells from HC. b. IV before and after PregS stimulation in a cell corresponding with (a.). c. IV before and after nifedipine stimulation in a cell corresponding with (a.). d. A representative time-series of current amplitude at + 100 mV and − 100 mV showing the effect of 100 μΜ PregS and 100 μM nifedipine on ionic currents in isolated NK cells from CFS/ME patients. e. IV before and after PregS stimulation in a cell as shown in (d.). f. IV before and after nifedipine stimulation in a cell as shown in (d.). g. Bar graphs representing TRPM3 current amplitude at + 100 mV after stimulation with 100 μΜ PregS and 100 μM nifedipine in CFS/ME patients (N = 6; n = 24) compared with HC (N = 6; n = 18). Data are represented as mean ± SEM. Abbreviations: CFS/ME, chronic fatigue syndrome/myalgic encephalomyelitis; HC, healthy controls; NK, natural killer; PregS, Pregnenolone sulfate; TRPM3, Transient Receptor Potential Melastatin 3

Back to article page