Circulating miR-26a-1, miR-146a and miR-199a-1 are potential candidate biomarkers for acute myocardial infarction

Xue, Sheng; Zhu, Wenjie; Liu, Dacheng; Su, Zhe; Zhang, Liwei; Chang, Qing; Li, Peifeng

doi:10.1186/s10020-019-0086-1

Molecular Medicine

Table 2 Relationships between miR-26a-1, miR-146a and miR-199a-1 and classical cardiovascular risk factors in patients with AMI and control subjects

From: Circulating miR-26a-1, miR-146a and miR-199a-1 are potential candidate biomarkers for acute myocardial infarction

Variable		AMI before PCI (n = 31)			AMI after PCI (n = 31)			Controls (n = 27)
Variable		miR-26a-1	miR-146a	miR-199a-1	miR-26a-1	miR-146a	miR-199a-1	miR-26a-1	miR-146a	miR-199a-1
Age (years)	r=	−0.150	−0.026	0.047	−0.211	0.123	0.083	0.249	0.319	0.011
Age (years)	p=	0.421	0.89	0.804	0.255	0.509	0.657	0.211	0.105	0.955
BMI (kg/m²)	r=	0.188	0.112	0.179	0.194	0.112	0.226	−0.117	− 0.370	− 0.050
BMI (kg/m²)	p=	0.310	0.550	0.336	0.295	0.550	0.222	0.560	0.856	0.803
SBP (mmHg)	r=	−0.020	0.063	−0.114	−0.061	−0.095	−0.026	0.021	−0.196	−0.283
SBP (mmHg)	p=	0.913	0.735	0.542	0.745	0.610	0.891	0.916	0.326	0.153
DBP (mmHg)	r=	−0.025	0.112	−0.202	−0.226	−0.151	−0.172	−0.206	−0.368	−0.124
DBP (mmHg)	p=	0.895	0.550	0.275	0.221	0.418	0.355	0.303	0.059	0.538
HP (cmp)	r=	0.035	0.055	0.069	0.015	−0.077	−0.190	0.071	0.096	0.279
HP (cmp)	p=	0.851	0.767	0.713	0.935	0.682	0.306	0.723	0.633	0.159
GLU (mmol/L)	r=	−0.150	0.022	0.146	−0.181	−0.041	0.068	−0.126	−0.190	−0.147
GLU (mmol/L)	p=	0.421	0.906	0.435	0.330	0.829	0.716	0.533	0.343	0.464
Tg (mmol/L)	r=	0.028	0.066	−0.188	−0.007	0.400	−0.031	−0.315	−0.325	0.240
Tg (mmol/L)	p=	0.881	0.726	0.311	0.969	0.832	0.868	0.110	0.098	0.228
Tc (mmol/L)	r=	−0.413	−0.143	−0.225	−0.115	− 0.161	− 0.118	− 0.074	− 0.264	− 0.136
Tc (mmol/L)	p=	0.021	0.444	0.166	0.540	0.387	0.527	0.713	0.184	0.500
HDL-C (mmol/L)	r=	0.145	−0.040	−0.099	−0.033	−0.278	−0.062	0.160	−0.207	0.041
HDL-C (mmol/L)	p=	0.437	0.831	0.598	0.861	0.130	0.742	0.425	0.299	0.839
LDL-C (mmol/L)	r=	−0.246	−0.046	−0.242	−0.074	−0.191	−0.012	−0.201	−0.297	−0.104
LDL-C (mmol/L)	p=	0.182	0.804	0.189	0.693	0.303	0.948	0.315	0.132	0.605
WBC (*10^9/L)	r=	−0.224	−0.255	−0.166	−0.060	−0.040	−0.212	0.051	0.321	0.345
WBC (*10^9/L)	p=	0.235	0.174	0.381	0.752	0.835	0.261	0.801	0.103	0.078
Cr (μmol/L)	r=	−0.110	−0.015	−0.062	−0.104	−0.046	−0.067	0.123	0.102	0.095
Cr (μmol/L)	p=	0.563	0.936	0.744	0.584	0.808	0.727	0.559	0.628	0.650
NT-proBNP (ng/mL)	r=	0.543	0.510	0.390	0.357	0.277	0.445	–	–	–
NT-proBNP (ng/mL)	p=	0.002	0.003	0.030	0.048	0.132	0.012	–	–	–
CK-MB (μg/L)	r=	0.008	−0.070	−0.060	−0.131	0.027	−0.096	−0.096	−0.199	−0.312
CK-MB (μg/L)	p=	0.965	0.715	0.753	0.489	0.887	0.615	0.655	0.351	0.138
Hs-cTNT (μg/L)	r=	0.472	0.457	0.396	0.390	0.455	0.378	–	–	–
Hs-cTNT (μg/L)	p=	0.007	0.013	0.033	0.030	0.013	0.043	–	–	–

r = Spearman rank correlation coefficients, p = p value. Values with statistical significance were indicated in bold. BMI Body mass index, DM Diabetes mellitus, SBP systolic blood pressure, DBP diastolic blood pressure, TC total cholesterol, TG total triglycerides, HDL high-density lipoprotein, LDL low-density lipoprotein, WBC white blood cell, Cr creatinine, CK-MB Creatine Kinase-MB, Hs-TNT troponin T

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