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Fig. 4 | Molecular Medicine

Fig. 4

From: Temporal progression of gene regulation of peripheral white blood cells explains gender dimorphism of critically ill patients after trauma

Fig. 4

The gene set cluster of the early pre-acute, pre-acute and acute phase. a The cluster consisted of 85 gene sets being downregulated in female patients. Most of these were associated to b energy metabolism and the mitochondrion (11 gene sets), c cell cycle (21 gene sets), d transcription and translation (26 gene sets), and d damage and repair (9 gene sets). For each category, their representative gene sets are listed here. The complete list is given in Additional file 1: Fig. S10. In comparison to healthy controls, for all categories, leukocytes of both sexes showed a lower expression of these gene sets, but relatively lower expression was observed in female patients. The z-transformed expression values were referred to as ‘scaled expression’ values. Significance of difference between the expression of genes of male and female patients was tested using two-sided Student’s t-tests (* P < 0.05, mean bar and Whiskers of the boxplots: mean ± se)

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