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Fig. 5 | Molecular Medicine

Fig. 5

From: Astragalus polysaccharides suppresses high glucose-induced metabolic memory in retinal pigment epithelial cells through inhibiting mitochondrial dysfunction-induced apoptosis by regulating miR-195

Fig. 5

APS decreased the RPE cells apoptosis via mitochondrial apoptotic pathway. a Western blotting showed treatment with APS significantly decreased the expression of Bax, cleaved caspase-9, cleaved caspase-3 and cleaved PARP which were induced by HG and HG + NG treatment, while increased the expression of Bcl-2 and uncleaved form of caspase-9, caspase-3 and PARP which were repressed by HG and HG + NG treatment in APRE-19 and PRPE cells. b and c. The statistical results of western blotting in APRE-19 and PRPE cells. Error bars represented mean ± SD. *** p < 0.001, ** p < 0.01, * p < 0.05

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Molecular Medicine

ISSN: 1528-3658