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Fig. 2 | Molecular Medicine

Fig. 2

From: CKD-602, a topoisomerase I inhibitor, induces apoptosis and cell-cycle arrest and inhibits invasion in cervical cancer

Fig. 2

Induction of G2/M arrest in cervical cancer cells following treatment with CKD-602. a. Cells were incubated with CKD602 in a dose-dependent manner (0, ½ IC50, IC50 ng/ml each cells) for 48 h. Cells were then harvested and fixed with ethanol followed by PI staining to determine cellular distribution in different phases of the cell cycle using flow cytometry. b. Percentage of cell cycle progression measured by flow cytometry. Results are expressed as the mean ± SEM (*p < 0.05 and **p < 0.01). c. Western blot analysis of cell cycle-related proteins in cervical cancer cells

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