A rare functional variant of SHARPIN attenuates the inflammatory response and associates with increased risk of late-onset Alzheimer’s disease

Table 1 Seven candidate risk variants for LOAD

Position (hg19)	Gene	Ref./Alt.	Protein	dbSNP ID	No. of carriers/No. determined
Position (hg19)	Gene	Ref./Alt.	Protein	dbSNP ID	LOAD	NC
12:120651694	PXN	T/C	p.Tyr487Cys	rs980452538	0/2176	0/909
8:145154709	SHARPIN	C/T	p.Gly186Arg	rs572750141	9/2172	0/916
8:145154228	SHARPIN	C/T	p.Gly292Arg	rs774802799	0/2183	0/917
19:10477232	TYK2	C/T	p.Val164Met	rs531355933	3/2181	0/916
7:148769094	ZNF786	C/T	p.Arg257His	rs771874615	0/2179	0/914
7:148767975	ZNF786	T/C	p.Tyr630Cys	rs762922242	0/2180	0/915
7:148767897	ZNF786	C/T	p.Gly656Asp	NA	0/2175	0/914

ISSN: 1528-3658