A rare functional variant of SHARPIN attenuates the inflammatory response and associates with increased risk of late-onset Alzheimer’s disease

Table 2 Associations of the two variants in SHARPIN and TYK2 with the risk of LOAD

dbSNP ID	Chr.	Gene	Phase	Number of samples		Number of variants		MAF		OR	95% CI	P	P (Bonferroni) ^b
dbSNP ID	Chr.	Gene	Phase	Cases	Controls	Cases	Controls	Cases	Controls	OR	95% CI	P	P (Bonferroni) ^b
rs572750141	8	SHARPIN	1st cohort	2383	13973	10	7	0.002	0.0003	8.4	3.2–22.1	2.28 × 10⁻⁷	1.6 × 10⁻⁶
			2nd cohort	2180	2486	1	1	0.0002	0.0002	1.14	0.02–89.5	1	1
			Combined^a	4563	16459	11	8	0.001	0.0002	6.1	2.4–15.5	1.15 × 10⁻⁵	8.05 × 10^− 5
rs531355933	19	TYK2	1st cohort	2379	13973	4	5	0.0008	0.0002	4.7	1.3–17.5	0.011	0.77
			2nd cohort	2180	2486	3	4	0.0007	0.0008	0.86	0.13–5.1	1	1
			Combined^a	4559	16459	7	9	0.0008	0.0003	1.93	0.71–5.2	0.26	1

ID; Identifier, Chr.; Chromosome, MAF; Minor allele frequency, OR; Odds ratio, CI; Confidence interval
^aP value was calculated by Mantel-Haenszel test
^bBonferroni-corrected P value, calculated by setting the number of tests to seven

ISSN: 1528-3658