Skip to main content

Table 2 Associations of the two variants in SHARPIN and TYK2 with the risk of LOAD

From: A rare functional variant of SHARPIN attenuates the inflammatory response and associates with increased risk of late-onset Alzheimer’s disease

dbSNP ID Chr. Gene Phase Number of samples Number of variants MAF OR 95% CI P P (Bonferroni) b
Cases Controls Cases Controls Cases Controls
rs572750141 8 SHARPIN 1st cohort 2383 13973 10 7 0.002 0.0003 8.4 3.2–22.1 2.28 × 10−7 1.6 × 10−6
2nd cohort 2180 2486 1 1 0.0002 0.0002 1.14 0.02–89.5 1 1
Combineda 4563 16459 11 8 0.001 0.0002 6.1 2.4–15.5 1.15 × 10−5 8.05 × 10− 5
rs531355933 19 TYK2 1st cohort 2379 13973 4 5 0.0008 0.0002 4.7 1.3–17.5 0.011 0.77
2nd cohort 2180 2486 3 4 0.0007 0.0008 0.86 0.13–5.1 1 1
Combineda 4559 16459 7 9 0.0008 0.0003 1.93 0.71–5.2 0.26 1
  1. ID; Identifier, Chr.; Chromosome, MAF; Minor allele frequency, OR; Odds ratio, CI; Confidence interval
  2. aP value was calculated by Mantel-Haenszel test
  3. bBonferroni-corrected P value, calculated by setting the number of tests to seven