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Fig. 3 | Molecular Medicine

Fig. 3

From: Electroacupuncture attenuated cerebral ischemic injury and neuroinflammation through α7nAChR-mediated inhibition of NLRP3 inflammasome in stroke rats

Fig. 3

Effect of EA stimulus on the expression of NLRP3 inflammasome. a Representative western immunoblotting analysis of NLRP3, Caspase-1 and IL-1β (n = 4). EA stimulus significantly decreased the levels of NLRP3, procaspase-1, Cl.Caspase-1, GSDMD, GSDMD-N, proIL-1β and mature IL-1β when compared with MCAO group. **P < 0.01, ***P < 0.001 vs. Sham group, ##P < 0.01, ###P < 0.001 vs. MCAO group. (b, c) Immunofluorescent staining of NLRP3, Caspase-1, neuronal nuclei (NeuN), and nuclear marker DAPI. EA stimulus decreased the levels of NLRP3 positive neurons and Caspase-1 positive neurons when compared with MCAO group. Scale bar = 30 μm

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Molecular Medicine

ISSN: 1528-3658