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Fig. 6 | Molecular Medicine

Fig. 6

From: Electroacupuncture attenuated cerebral ischemic injury and neuroinflammation through α7nAChR-mediated inhibition of NLRP3 inflammasome in stroke rats

Fig. 6

EA stimulus regulates the balance between proinflammatory factors and anti-inflammatory cytokines through α7nAChR. Representative ELISA analysis of proinflammatory factors IL-18 (a), TNF-α (b) and anti-inflammatory cytokines TGF-β1 (c), IL-10 (d) (n = 8 for each group). Compared with sham group, cerebral I/R injury up-regulated the levels of IL-18, TNF-α and TGF-β1, IL-10. EA stimulus down-regulated the levels of proinflammatory factors (IL-18, TNF-α) and up-regulated the contents of anti-inflammatory cytokines (TGF-β1, IL-10) as compared to MCAO group. Intraperitoneal injection of PHA-543,613 exerted similar beneficial effects as that of EA stimulus. Meanwhile, the administration of α7nAChR antagonist α-BGT reversed the effects of EA stimulus. *P < 0.05, ***P < 0.001 vs. Sham group, #P < 0.05, ##P < 0.01 vs. MCAO group, &P < 0.05 vs. EA + MCAO group

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Molecular Medicine

ISSN: 1528-3658