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Fig. 8 | Molecular Medicine

Fig. 8

From: Electroacupuncture attenuated cerebral ischemic injury and neuroinflammation through α7nAChR-mediated inhibition of NLRP3 inflammasome in stroke rats

Fig. 8

α7nAChR was involved in the neuroprotective effects of EA stimulus. Representative TTC staining of the cerebral infarct (a), infarct volume (b) and neurologic score (c) at 3 days after reperfusion (n = 8). Red area represents live tissue; and white area represents dead or dying tissue. The infarct volume of EA + MCAO group was significantly reduced and the neurological score was improved when compared with MCAO group. Compared with EA + MCAO group, the infarct volume of α-BGT + EA + MCAO group was significantly increased and neurological score was reduced. When compared with MCAO group, intraperitoneal injection of PHA-543,613 decreased the infarct size and alleviated neurological deficits. #P < 0.05, ##P < 0.01 vs. MCAO group, &P < 0.05 vs. EA + MCAO group

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Molecular Medicine

ISSN: 1528-3658